ArticleClinical & experimental ophthalmology2022
Quality of life impact of eye diseases: a Save Sight Registries study.
Article in Clinical & experimental ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Association Between Keratoconus and Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Cornea · 2026Pooled it
- Artificial intelligence and patient reported outcomes in ophthalmology.Journal of patient-reported outcomes · 2026Pooled it
- What is the quality-of-life status of patients with keratoconus who have not had a surgical intervention? A systematic review.Eye (London, England) · 2025Pooled it
- Pulsed corneal crosslinking in the treatment of Keratoconus: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 2000 to 2020.Eye (London, England) · 2024Pooled it
- Living Well with Keratoconus: Implications for Person-Centred Eye Care.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Patient-Reported Visual Function and Vision-Related Quality of Life Across Ophthalmic Diseases: An Exploratory Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Trends in the Management of Keratoconus in Australia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Article
- Impact of individualized colored spectacle filters on photophobia and visual comfort in central visual field defect patients: a one-year study.Scientific reports · 2026Article
- Evaluation of Factors Influencing Quality of Life in Keratoconus Patients Using the Keratoconus Outcomes Research Questionnaire (KORQ).Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- International corneal and ocular surface disease dataset for electronic health records.The British journal of ophthalmology · 2025Article
- Reduced quality of life in corneal dystrophy - a prospective case control study.BMC ophthalmology · 2025Article
- Clinical and Socioeconomic Burden of Retinal Diseases: Can Biosimilars Add Value? A Narrative Review.Ophthalmology and therapy · 2025Review
- Enhancing early detection of keratoconus suspects using interocular corneal tomography asymmetry.International ophthalmology · 2025Article
- Chinese burdens and trends of diabetic retinopathy 1990-2021 and 15 years forecast: results from the Global Burden of Disease Study 2021.Frontiers in endocrinology · 2025Article
- Impacts of keratoconus on quality of life: a qualitative study.Eye (London, England) · 2024Article
- The Chinese keratoconus (CKC) cohort study.European journal of epidemiology · 2024Article
- Effect of autologous serum after amniotic membrane transplantation for persistent corneal ulcers.International journal of ophthalmology · 2024Article
- Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions: theoretical basis.International journal of ophthalmology · 2024Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe objectives of this study were to evaluate the quality-of-life (QoL) impact of eye diseases (keratoconus; neovascular age-related macular degeneration, AMD; retinal vein occlusion, RVO; and diabetic macular edema, DME) using the Impact of Vision Impairment (IVI) questionnaire, and to determine the relationship between the IVI scores and visual acuity.
methodsThis cross-sectional, multicentre, real-world study utilised the prospective, web-based Save Sight Registries. The IVI was completed by 1557 patients: 307 with keratoconus, 1049 with AMD, 148 with RVO and 53 with DME. Statistical analysis included Rasch analysis, Welch t-test, one-way ANOVA, Tukey's test, Pearson correlation, and multiple regression.
resultsThe IVI scales (Overall; Visual Function, VF; Emotional, EM) had robust psychometric properties. The keratoconus patients had the worst Overall (adjusted mean: 48.2 vs. DME 58.8, RVO 64.6, AMD 67.6 units), VF (47.7 vs. DME 59.4, RVO 65.9, AMD 68.9 units) and EM (50.8 vs. DME 63.1, RVO 69.2, AMD 71.8 units) scores (all p < 0.05). The IVI scales scores weakly correlated with better and worse eye visual acuity (Pearson's r 0.24-0.39, all p < 0.05). The correlations were similar in the better eye (Overall 0.35, VF 0.39, EM 0.24) and the worse eye (Overall 0.31, VF 0.33, EM 0.25) visual acuity. Correlations with visual acuity were stronger for VF than for the EM scores.
conclusionsThe IVI was a psychometrically robust QoL questionnaire. Keratoconus patients had worse IVI scores than patients with retinal diseases. The low strength of correlations between visual acuity and QoL scores, although statistically significant, suggested that a complex relationship exists.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.