Evidence map›Paper›PMID 35080648›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Visual deterioration in patients with photoreceptor loss after retinal reattachment surgery.

Sana Rasool, Megha Kaushik, Rishika Chaudhary, Karen Blachford, Martin Berry, Robert A H Scott, Ann Logan, Richard J Blanch

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Metamorphopsia after surgery for rhegmatogenous retinal detachment.International journal of ophthalmology · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Sana RasoolSandwell & West Birmingham NHS Trust, Birmingham, UK.
Megha KaushikDepartment of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Rishika ChaudharyDepartment of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Karen BlachfordSandwell & West Birmingham NHS Trust, Birmingham, UK.
Martin Berry
Robert A H ScottNeuroscience & Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Ann LoganAxolotl Consulting Ltd, Droitwich, WR9 0JS, Worcestershire, UK.
Richard J BlanchDepartment of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. R.J.Blanch@bham.ac.uk.
Sandwell & West Birmingham Hospitals NHS Trust · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBNIHR Surgical Reconstruction and Microbiology Research Centre · GBUniversity of Birmingham · GBUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAssess the relationship between photoreceptor degeneration and visual function after retinal reattachment surgery (RRS) in a prospective cohort.

methodsPatients with rhegmatogenous retinal detachment (RRD) were reviewed before and 6 months after vitreoretinal surgery. Optical coherence tomographical thickness of the outer nuclear layer (ONL), outer retinal segment (ORS), retinal pigmented epithelium to ellipsoid zone (RPE-EZ) and external limiting membrane to EZ (ELM-EZ) were recorded 6 months post-operatively. These were compared to best corrected visual acuity (BCVA) and retinal sensitivity (Humphrey visual field).

resultsThirteen macula-off and 8 macula-on RRD patients were included. The mean ONL thickness was higher after macula-on RRD compared to macula-off RRD (97.70 ± 3.62 μm vs. 73.10 ± 4.98 μm). In all RRD eyes, every 1 μm decrease in ONL thickness correlated with a 0.052 dB decrease and in retinal sensitivity and every 1 μm decrease in ORS thickness was associated with a 0.062 dB reduction in retinal sensitivity. ORS, ELM-EZ and RPE-EZ thickness did not correlate with BCVA post-RRS.

conclusionThere was greater ONL and ORS thinning following macula-off compared to macula-on RRD. Correlations between ONL and ORS thinning with decreased retinal sensitivity may be explained by RRD-induced photoreceptor death.

Indexed as

Macula LuteaRetinal DegenerationRetinal DetachmentHumansProspective StudiesRetinaRetrospective StudiesTomography, Optical CoherenceVisual AcuityApoptosisOCTPhotoreceptorsRetinal detachmentVisual acuityVisual field

Identifiers

PMID35080648
PMCPMC9203401
OpenAlexW4210397006

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.