ArticlemSphere2022
Expanding the Pathogenic Potential Concept To Incorporate Fulminancy, Time, and Virulence Factors.
Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Insights into Persian Gulf Beach Sand Mycobiomes: Promises and Challenges in Fungal Diversity.Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- A Cryptococcus neoformans polysaccharide conjugate vaccine made with filtered polysaccharide elicits protective immunity in mice.Fungal biology · 2025Article
- Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice.Nature microbiology · 2025Article
- Cell wall melanin impedes growth of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comparative Cross-Kingdom DDA- and DIA-PASEF Proteomic Profiling Reveals Novel Determinants of Fungal Virulence and a Putative Druggable Target.Journal of proteome research · 2024Article
- mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease.mSphere · 2024Article
- Article
- Co-evolution within the plant holobiont drives host performance.EMBO reports · 2023Review
- "It Is Not Necessary to Kill Them in Order to Make Them Relatively Harmless": Molecular Diplomacy in the Pathogen-Host Interaction.Surgical infections · 2023Article
- On the relationship between Pathogenic Potential and Infective Inoculum.PLoS pathogens · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The pathogenic potential (PP) concept posits that all microorganisms have some pathogenic potential that can be calculated by an equation that includes the fraction symptomatic, inoculum, and mortality fraction. The PP concept dispenses with characterizing microbes as pathogens, nonpathogens, commensals, pathobionts, etc., by providing an alternative approach to the problem of virulence that considers the contributions of both the host and the microbe. Here, the PP concept is extended to incorporate the role of time in virulence by introducing a new parameter, fulminancy, which is a measure of the rapidity of the pathogenic process. Fulminancy allows PP calculations in situations where all hosts are affected equally, but the process occurs later for attenuated strains. Differences in the PP of wild-type and mutant microbes lacking virulence factors can be used to estimate the contribution of virulence factors to the pathogenic process, thus providing a new quantitative approach to these important pathogenicity parameters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.