Evidence map›Paper›PMID 35080420›Full record

ArticleJournal of neurophysiology2022

Imbalance and dizziness caused by unilateral vestibular schwannomas correlate with vestibulo-ocular reflex precision and bias.

Susan King, Kilian Dahlem, Faisal Karmali, Konstantina M Stankovic, D Bradley Welling, Richard F Lewis

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07627087 (Vestibular Implant Tested in Patients With Peripheral Vestibular Damage), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07627087 narecruitingnot on this mapstarted 2026, after this paper: background citation

Vestibular Implant Tested in Patients With Peripheral Vestibular Damage: Effects on Spatial Orientation, Navigation, and Neuropsychologic Function

TypeinterventionalSponsorMassachusetts Eye and Ear InfirmaryRan2026 to 2029Enrolled20ConditionsVestibular Dysfunction, Bilateral Vestibular Loss, Vestibular ImplantArmsvestibular implant stimulation
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. How Peripheral Vestibular Damage Affects Velocity Storage: a Causative Explanation.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Susan KingJenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear, Boston, Massachusetts.
Kilian DahlemJenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear, Boston, Massachusetts.
Faisal KarmaliJenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear, Boston, Massachusetts.ORCID 0000-0002-1140-4954
Konstantina M StankovicDepartment of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
D Bradley WellingDepartment of Otolaryngology, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9963-469X
Richard F LewisJenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear, Boston, Massachusetts.ORCID 0000-0002-9231-3658
Massachusetts Eye and Ear Infirmary · USHarvard University · US

Funding

Vestibular Precision: Physiology and PathophysiologyR01DC018287 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI KARMALI, FAISAL, LEWIS, RICHARD F · 2020 to 2024
$2.4M
NIDCD NIH HHS R01 DC018287
6 · The paper itself

Abstract

Imbalance and dizziness are disabling symptoms for many patients with vestibular schwannomas (VS) but symptom severity typically does not correlate with the vestibulo-ocular reflex (VOR) amplitude-based metrics used to assess peripheral vestibular damage. In this study, we tested the hypothesis that imbalance and dizziness in patients with VS relate to VOR metrics that are not based on response amplitude. Twenty-four patients with unilateral, sporadic VS tumors were studied, and objective (balance) and subjective (dizziness) vestibular dysfunction was quantified. The VOR was tested using two yaw-axis motion stimuli, low-frequency en-bloc sinusoidal, and high-frequency head-on-body impulsive rotations. Imbalance correlated with VOR

Indexed as

AdultDizzinessFemaleHumansMaleMiddle AgedNeuroma, AcousticPostural BalanceReflex, Vestibulo-Oculareye movementsschwannomatestingvestibularvestibulo-ocular reflex

Identifiers

PMID35080420
PMCPMC8858680
OpenAlexW4210468193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.