Evidence map›Paper›PMID 35080396›Full record

ArticleJournal of medicinal chemistry2022

Discovery of Novel Inhibitors of Uridine Diphosphate-

Marta Acebrón-García-de-Eulate, Joan Mayol-Llinàs, Matthew T O Holland, So Yeon Kim, Karen P Brown, Chiara Marchetti, Jeannine Hess, Ornella Di Pietro, Vitor Mendes, Chris Abell and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Marta Acebrón-García-de-EulateDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.ORCID 0000-0002-6035-7525
Joan Mayol-LlinàsYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Matthew T O HollandYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
So Yeon KimDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.
Karen P BrownMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.
Chiara MarchettiYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Jeannine HessYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0001-5916-0728
Ornella Di PietroYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Vitor MendesDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.ORCID 0000-0002-2734-2444
Chris AbellYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
R Andres FlotoMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.
Anthony G CoyneYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0003-0205-5630
Tom L BlundellDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.
University of Cambridge · GBMRC Laboratory of Molecular Biology · GB

Funding

Department of HealthWellcome Trust 107032Wellcome Trust 107032AIA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBinding SitesCatalytic DomainCrystallography, X-RayCystic FibrosisDrug Evaluation, PreclinicalHumansLigandsMolecular ConformationMolecular Docking SimulationOxidoreductasesPseudomonas aeruginosaPseudomonas InfectionsPyrazolesAnti-Bacterial AgentsBacterial ProteinsLigandsOxidoreductasespyrazolePyrazoles

Identifiers

PMID35080396
PMCPMC7614804
OpenAlexW4210760866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.