Evidence map›Paper›PMID 35080298›Full record

ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2022

Novel artful applications of vaccines at the horizon.

Davide Montin, Giorgio Ottaviano, Maria Sangerardi, Mayla Sgrulletti, Loredana Chini, Rosa Maria Dellepiane, Baldassarre Martire, Caterina Rizzo, Viviana Moschese

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Novel artful applications of vaccines at the horizon.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Davide MontinImmunology and Rheumatology Unit, Regina Margherita Children Hospital, Turin, Italy.ORCID 0000-0001-8953-2182
Giorgio OttavianoMolecular and Cellular Immunology Unit, Great Ormond Street Institute of Child Health, University College of London, London, United Kingdom.ORCID 0000-0003-3777-0394
Maria SangerardiDepartment of Pediatrics and Emergency, Azienda Ospedaliero Universitaria Consorziale Policlinico, Ospedale Pediatrico Giovanni XXIII, Bari, Italy.
Mayla SgrullettiPediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata, Policlinico Tor Vergata, Rome, Italy.
Loredana ChiniPediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata, Policlinico Tor Vergata, Rome, Italy.
Rosa Maria DellepianePediatric Intermediate Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Baldassarre MartirePediatrics and Neonatology Unit, Maternal-Infant Department, Monsignor A.R. Dimiccoli Hospital, Barletta, Italy.
Caterina RizzoInnovation and Clinical Pathways Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Viviana MoschesePediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata, Policlinico Tor Vergata, Rome, Italy.ORCID 0000-0001-7650-0632
University of Rome Tor Vergata · ITBambino Gesù Children's Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITGreat Ormond Street Hospital · GBOspedale degli Infermi · ITOspedale Pediatrico Giovanni XXIII · ITOspedale Regina Margherita · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some live vaccines, particularly Bacillus Calmette-Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all-cause mortality by outreaching the mere control of specific infections and exerting off-target effects. Asides from the prevention of viral infection, some other vaccines, such as those against flu or rotavirus, could reduce the risk of developing autoimmunity. The nonspecific effects of vaccines are mediated by the innate immune system, mainly through the so-called trained innate immunity. These observations paved the way for developing tolerogenic and trained immunity-based vaccines with substantial implications for more effective use of vaccines and combat vaccine hesitancy.

Indexed as

BCG VaccineVirus DiseasesHumansImmunity, InnateMeasles VaccineBCG VaccineMeasles VaccineautoimmunityBCGdiabetesmeaslesmRNA vaccinesnonspecific effectsvaccines

Identifiers

PMID35080298
PMCPMC9543439
OpenAlexW4210271822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.