Evidence map›Paper›PMID 35079977›Full record

SynthesisAging clinical and experimental research2022

Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials.

Lorenzo Lippi, Alessandro de Sire, Kamal Mezian, Claudio Curci, Luca Perrero, Alessio Turco, Silvia Andaloro, Antonio Ammendolia, Nicola Fusco, Marco Invernizzi

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  10. Rethinking Osteoporosis Drugs: Can We Simultaneously Address Sarcopenia?International journal of molecular sciences · 2025
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  13. Frontiers in pain research (Lausanne, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Lorenzo LippiDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
Alessandro de SireDepartment of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy. alessandro.desire@unicz.it.ORCID http://orcid.org/0000-0002-5541-8346
Kamal MezianDepartment of Rehabilitation Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Claudio CurciPhysical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, Mantova, Italy.
Luca PerreroRehabilitation Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Alessio TurcoRehabilitation Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Silvia AndaloroDivision of Pathology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Antonio AmmendoliaDepartment of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
Nicola FuscoDivision of Pathology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Marco InvernizziDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITMagna Graecia University · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITAzienda Ospedaliera Carlo Poma · ITCharles University · CZUniversity of Milan · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious evidence showed that cellular aging is a multifactorial process that is associated with decline in mitochondrial function. Physical exercise has been proposed as an effective and safe therapeutical intervention to improve the mitochondria network in the adult myocytes.

aimsThe aim of this systematic review of randomized controlled trials (RCTs) was to assess the exercise-induced muscle mitochondria modifications in older adults, underlining the differences related to different exercise modalities.

methodsOn November 28th, 2021, five databases (PubMed, Scopus, Web of Science, Cochrane, and PEDro) were systematically searched for RCTs to include articles with: healthy older people as participants; physical exercise (endurance training (ET), resistance training (RT), and combined training (CT)) as intervention; other different exercise modalities or physical inactivity as comparator; mitochondrial modifications (quality, density and dynamics, oxidative, and antioxidant capacity) as outcomes. The quality assessment was performed according to the PEDro scale; the bias risk was evaluated by Cochrane risk-of-bias assessment tool.

resultsOut of 2940 records, 6 studies were included (2 assessing ET, 2 RT, 1 CT, and 1 both ET and RT). Taken together, 164 elderly subjects were included in the present systematic review. Significant positive effects were reported in terms of mitochondrial quality, density, dynamics, oxidative and antioxidant capacity, even though with different degrees according to the exercise type. The quality assessment reported one good-quality study, whereas the other five studies had a fair quality. DISCUSSION: The overall low quality of the studies on this topic indicate that further research is needed.

conclusionRT seems to be the most studied physical exercise modality improving mitochondrial density and dynamics, while ET have been related to mitochondrial antioxidant capacity improvements. However, these exercise-induced specific effects should be better explored in older people.

Indexed as

AntioxidantsResistance TrainingAgedExerciseHumansMitochondria, MuscleQuality of LifeRandomized Controlled Trials as TopicAntioxidantsAgingElderlyMitochondriaMusclePhysical exercisePrecision medicineQuality of lifeRehabilitation

Identifiers

PMID35079977
OpenAlexW4206900841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.