Evidence map›Paper›PMID 35079949›Full record

ArticleProbiotics and antimicrobial proteins2022

Supplementation of Bacillus sp. DU-106 Alleviates Antibiotic-Associated Diarrhea in Association with the Regulation of Intestinal Microbiota in Mice.

Darong Huang, Yanlan Chen, Hongzhu Chen, Xinyu Deng, Jianzhao Huang, Siming Lu, Pan Li, Bing Du

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  7. Effects ofNutrients · 2023
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  9. Regulatory Effect ofFrontiers in nutrition · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Darong HuangCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Yanlan ChenCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Hongzhu ChenCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Xinyu DengCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jianzhao HuangCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Siming LuCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Pan LiCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China. lp19900815@scau.edu.cn.
Bing DuCollege of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China. dubing@scau.edu.cn.
South China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacillus sp. DU-106, a potential probiotic, has been proved to activate innate immunity, reduce hypercholesterolemia, and regulate the gut microbiota of mice. In the present study, we investigated the therapeutic effect of strain DU-106 in antibiotic-associated diarrhea (AAD) via analyzing the changes in gut microbial composition in mice. The results indicated that supplementation of strain DU-106 alleviated gastrointestinal symptoms, improved gut barrier integrity and immunoglobulin-A level of mice with AAD. A 16S rRNA sequencing showed that antibiotics decreased bacterial diversity and the abundances of Alistipes, Roseburia, Hungatella, Eubacterium-xylanophilum, Lachnospiraceae-UCG-001, Intestinimonas, and Lachnospiraceae-NK4A136, but increased the abundance of Klebsiella, Bacteroidota, and Verrucomicrobiota. However, strain DU-106 treatment reversed these alternations in mice with AAD. In conclusion, strain DU-106 could alleviate AAD in association with the regulation of intestinal microbiota and could be used as an alternative treatment for AAD.

Indexed as

BacillusGastrointestinal MicrobiomeProbioticsAnimalsAnti-Bacterial AgentsDiarrheaMiceRNA, Ribosomal, 16SAnti-Bacterial AgentsRNA, Ribosomal, 16S16S rRNA sequencingAAD miceAntibioticsGut barrier integrityGut floraHistopathologyProbiotics

Identifiers

PMID35079949
OpenAlexW4210687371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.