ArticleCancer causes & control : CCC2022
Periodontal disease as a risk factor for sporadic colorectal cancer: results from COLDENT study.
Article in Cancer causes & control : CCC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies.BMC cancer · 2026Pooled it
- The impact of systemic administration of polyphenols on periodontitis associated with diabetes mellitus: a systematic review.Acta odontologica Scandinavica · 2024Pooled it
- Periodontitis prevalence and effects on postoperative complications in gastric surgery: a prospective observational study.BMC oral health · 2026Observational
- Increased Production of Angiopoietin-like Protein 2 in a Ligature- and LPS-Induced Periodontitis Mouse Model May Promote Colorectal Tumor Progression.Journal of clinical medicine · 2026Article
- Periodontitis, colorectal cancer and associated factors: A cross-sectional study.Journal of clinical and experimental dentistry · 2026Review
- Red Complex Periodontal Pathogens and Their Potential Role in Colorectal Carcinogenesis: A Narrative Review.International journal of molecular sciences · 2025Review
- Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance.Metabolites · 2025Article
- Periodontitis as a field of cancerization: association with carcinoembryonic antigen in colorectal cancer patients.Clinical oral investigations · 2025Article
- Association between periodontitis and gastrointestinal cancer risk and prognosis: evidence from a nested case-control study in Southwest China.European journal of medical research · 2025Article
- Article
- Photobiomodulation and the oral-gut microbiome axis: therapeutic potential and challenges.Frontiers in medicine · 2025Review
- Evaluation of Periodontitis andHealthcare (Basel, Switzerland) · 2024Article
- Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Interaction between periodontal disease and colorectal cancer: implications of oral microbiota in carcinogenesis.EXCLI journal · 2024Article
- Who is in the driver's seat? Parvimonas micra: An understudied pathobiont at the crossroads of dysbiotic disease and cancer.Environmental microbiology reports · 2023Review
- Oral-Gut Microbiota, Periodontal Diseases, and Arthritis: Literature Overview on the Role of Probiotics.International journal of molecular sciences · 2023Review
- Emerging roles for lncRNA-NEAT1 in colorectal cancer.Cancer cell international · 2022Review
- Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study.Scientific reports · 2022Article
- Involvement ofFrontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Colorectal cancer remains the top leading cancer worldwide. Accumulating evidence suggests periodontal pathogens are involved in colorectal carcinogenesis, indicating the need for high-quality epidemiological evidence linking periodontal disease (PD) and colorectal cancer (CRC). Thus, we conducted the first population-based case-control study that was specifically designed to investigate the association between compromised oral health and sporadic CRC. A total of 348 incident cases of colon or rectal cancer, and 310 age and sex frequency-matched controls, from the Montreal island and Laval population participated in the study. Data were collected on PD and on several CRC risk factors using validated questionnaires. A life-course approach was used to document long-term history regarding lifestyle factors. Multivariable unconditional logistic regression analysis was used to estimate the rate ratio (RR) quantifying the association between CRC and PD. Results showed that the rate of new diagnosis of CRC in persons with a positive history of PD was 1.45 times higher than in those with a negative history of PD adjusting for age, sex, BMI, education, income, diabetes, family history of CRC, regular use of non-steroidal anti-inflammatory drugs, lifetime cumulative smoking, lifetime consumption of red meats, processed meats, and alcoholic drinks, and lifetime total physical activity score (adjusted RR = 1.45; 95% CI 1.04-2.01; p = 0.026). Our results support the hypothesis of an association between PD and sporadic CRC risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.