Evidence map›Paper›PMID 35079787›Full record

Trial reportEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2022

Standard care vs. TRIVEntricular pacing in Heart Failure (STRIVE HF): a prospective multicentre randomized controlled trial of triventricular pacing vs. conventional biventricular pacing in patients with heart failure and intermediate QRS left bundle branch block.

Justin Gould, Simon Claridge, Thomas Jackson, Benjamin J Sieniewicz, Baldeep S Sidhu, Bradley Porter, Mark K Elliott, Vishal Mehta, Steven Niederer, Humra Chadwick and 11 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02529410 (A Multicentre Randomised Control Trial Comparing Standard Cardiac Resynchronisation Pacing With Triventricular Pacing), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02529410 phase3unknown statusnot on this map

A Multicentre Randomised Control Trial Comparing Standard Cardiac Resynchronisation Pacing With Triventricular Pacing

TypeinterventionalSponsorGuy's and St Thomas' NHS Foundation TrustRan2015 to 2017Enrolled100ConditionsHeart FailureArmsCardiac Resynchronisation Therapy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Justin GouldGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.ORCID 0000-0002-1897-5565
Simon ClaridgeGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Thomas JacksonGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Benjamin J SieniewiczGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Baldeep S SidhuGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Bradley PorterGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Mark K ElliottGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.ORCID 0000-0003-2805-3043
Vishal MehtaGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.ORCID 0000-0001-6140-068X
Steven NiedererKing's College London, Westminster Bridge Road, London, SE1 7EH, UK.ORCID 0000-0002-4612-6982
Humra ChadwickGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Ravi KamdarCroydon University Hospital, 530, London Road, Croydon, CR7 7YE, UK.
Shaumik AdhyaMaritime Hospital, Windmill Road, Gillingham, Kent, ME7 5NY, UK.
Nikhil PatelEastbourne District General Hospital, King's Drive, Eastbourne, East Sussex, BN21 2UD, UK.
Shoaib HamidQueen Elizabeth Hospital, Stadium Road, London, SE18 4QH, UK.
Dominic RogersNorthen General Hospital, Herries Road, Sheffield, South Yorkshire, S5 7AU, UK.
William NicolsonGlenfield Hospital, Groby Road, Leicester, Leicestershire, LE3 9QP, UK.
Cheuk F ChanEast Surrey Hospital, Canada Avenue, Redhill, RH1 5RH, UK.
Zachary WhinnettHammersmith Hospital, Du Cane Road, London W12 0HS, UK.
Francis MurgatroydKing's College Hospital, Denmark Hill, London, SE5 9RS, UK.
Pier D LambiaseBarts Heart Centre, St Bartholomew's Hospital, West Smithfield, City of London, EC1A 7BE, UK.
Christopher A RinaldiGuy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.

Funding

BHF PG/15/91/31812British Heart Foundation FS/13/44/30291Engineering and Physical Sciences Research Council Centre for Medical Engineering WT203148/Z/16/ZEPSRC EP/P01268X/1MicroPort and MedtronicMicroPort Cardiac Rhythm ManagementNational Institute for Health ResearchNIHRWellcome TrustWellcome Trust WT203148/Z/16/Z
6 · The paper itself

Abstract

aimsTo determine whether triventricular (TriV) pacing is feasible and improves CRT response compared to conventional biventricular (BiV) pacing in patients with left bundle branch block (LBBB) and intermediate QRS prolongation (120-150 ms). METHODS AND

resultsBetween October 2015 and November 2019, 99 patients were recruited from 11 UK centres. Ninety-five patients were randomized 1:1 to receive TriV or BiV pacing systems. The primary endpoint was feasibility of TriV pacing. Secondary endpoints assessed symptomatic and remodelling response to CRT. Baseline characteristics were balanced between groups. In the TriV group, 43/46 (93.5%) patients underwent successful implantation vs. 47/49 (95.9%) in the BiV group. Feasibility of maintaining CRT at 6 months was similar in the TriV vs. BiV group (90.0% vs. 97.7%, P = 0.191). All-cause mortality was similar between TriV vs. BiV groups (4.3% vs. 8.2%, P = 0.678). There were no significant differences in echocardiographic LV volumes or clinical composite scores from baseline to 6-month follow-up between groups.

conclusionImplantation of two LV leads to deliver and maintain TriV pacing at 6 months is feasible without significant complications in the majority of patients. There was no evidence that TriV pacing improves CRT response or provides additional clinical benefit to patients with LBBB and intermediate QRS prolongation and cannot be recommended in this patient group. CLINICAL TRIAL REGISTRATION NUMBER: Clinicaltrials.gov: NCT02529410.

Indexed as

Cardiac Resynchronization TherapyHeart FailureBundle-Branch BlockHumansProspective StudiesTreatment OutcomeCardiac resynchronization therapyImproving cardiac resynchronization therapy responseMulti-lead left ventricular pacingMulti-site pacingTriventricular pacing

Identifiers

PMID35079787
PMCPMC9071069

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.