Evidence map›Paper›PMID 35079727›Full record

ArticleCell reports methods2021

Macrophage calcium reporter mice reveal immune cell communication

Nika Taghdiri, David M Calcagno, Zhenxing Fu, Kenneth Huang, Rainer H Kohler, Ralph Weissleder, Todd P Coleman, Kevin R King

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Macrophages at the Crossroads of Chronic Stress and Cancer.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nika TaghdiriDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, 9500 Gilman Dr. MC 0412, La Jolla, CA 92093, USA.
David M CalcagnoDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, 9500 Gilman Dr. MC 0412, La Jolla, CA 92093, USA.
Zhenxing FuDivision of Cardiology and Cardiovascular Institute, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Kenneth HuangDivision of Cardiology and Cardiovascular Institute, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Rainer H KohlerCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA, USA.
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA, USA.
Todd P ColemanDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, 9500 Gilman Dr. MC 0412, La Jolla, CA 92093, USA.
Kevin R KingDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, 9500 Gilman Dr. MC 0412, La Jolla, CA 92093, USA.
University of California San Diego · USHarvard University · US

Funding

Quantitative nanoparticle imaging of macrophagesR01HL131495 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, WEISSLEDER, MD, PHD, RALPH · 2017 to 2020
$2.7M
Elucidating Cell Communication Networks during Tissue Inflammation, Fibrosis, and RegenerationDP2AR075321 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KING, KEVIN R · 2018 to 2018
$2.4M
Imaging tumor associated macrophage (TAM) functionR01CA206890 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL, WEISSLEDER, MD, PHD, RALPH · 2017 to 2021
$1.9M
Single Cell Imaging of the HeartR01HL122208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2014 to 2017
$1.7M
Danger Signaling and Spread of Injury after Myocardial InfarctionR00HL129168 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KING, KEVIN R · 2017 to 2019
$746k
NCI NIH HHS R01 CA206890NHLBI NIH HHS R00 HL129168NHLBI NIH HHS R01 HL122208NHLBI NIH HHS R01 HL131495NIAMS NIH HHS DP2 AR075321
6 · The paper itself

Abstract

Cell communication underlies emergent functions in diverse cell types and tissues. Recent evidence suggests that macrophages are organized in communicating networks, but new tools are needed to quantitatively characterize the resulting cellular conversations. Here, we infer cell communication from spatiotemporal correlations of intracellular calcium dynamics that are non-destructively imaged across cell populations expressing genetically encoded calcium indicators. We describe a hematopoietic calcium reporter mouse (Csf1r

Indexed as

Calcium, DietaryMacrophagesAnimalsCell CommunicationMiceCalcium, Dietary

Identifiers

PMID35079727
PMCPMC8786215
OpenAlexW4200372435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.