Evidence map›Paper›PMID 35079723›Full record

ArticleAmerican heart journal plus : cardiology research and practice2021

Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.

Mohammed Elzeneini, Mohammad Al-Ani, Anthony E Peters, Marie D Burdick, Ning Yang, Michael Salerno, Borna Mehrad, Ellen C Keeley

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Article in American heart journal plus : cardiology research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mohammed ElzeneiniDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Mohammad Al-AniDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Anthony E PetersDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Marie D BurdickDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Ning YangDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Michael SalernoDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Borna MehradDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Ellen C KeeleyDepartment of Medicine, University of Florida, Gainesville, FL, USA.

Funding

Multiscale modeling of the role of heme during invasive pulmonary aspergillosisR01AI135128 · NIAID · UNIVERSITY OF FLORIDA · PI REINHARD LAUBENBACHER, Borna Mehrad · 2018 to 2026
$4.9M
Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens.U01EB024501 · NIBIB · UNIVERSITY OF FLORIDA · PI LAUBENBACHER, REINHARD, MEHRAD, BORNA · 2017 to 2020
$2.9M
Fibrocytes in human pulmonary fibrosisR01HL098329 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA, ROSE, C EDWARD · 2011 to 2015
$2.7M
NHLBI NIH HHS R01 HL098329NIAID NIH HHS R01 AI135128NIBIB NIH HHS U01 EB024501
6 · The paper itself

Abstract

STUDY

objectiveInfarct size is a strong predictor of outcomes after ST elevation myocardial infarction (STEMI). Circulating fibrocytes are bone marrow-derived progenitor cells associated with fibrotic processes. We tested whether fibrocytes correlate with infarct size in STEMI patients treated with primary percutaneous coronary intervention (PCI).

designProspective observational study.

settingAcademic medical center.

participantsSubjects with STEMI treated with primary PCI.

interventionsPeripheral blood draw and cardiac magnetic resonance imaging (CMR).

main outcome measureCorrelation of fibrocyte levels with infarct size.

methodsPeripheral blood fibrocytes were quantified at discharge from STEMI hospitalization and at 6 months follow-up using flow cytometry. Infarct size was determined within 2 weeks of discharge and at 6 months follow-up using late gadolinium enhancement on CMR.

resultsAmong 14 patients (median age 54 years, 79% men) with STEMI, there was a statistically significant positive correlation between fibrocyte levels at 6 months and 6-month infarct size on CMR (r = 0.58, p = 0.031). In addition, there was positive correlation between peak troponin I level (r = 0.85, p < 0.001), and white blood cell count (r = 0.55, p = 0.042) during the hospital stay and 6-month infarct size on CMR.

conclusionsCirculating fibrocytes measured 6 months after STEMI positively correlate with 6-month infarct size assessed by CMR.

Indexed as

BiomarkerFibrocyteInfarct sizeST elevation myocardial infarction

Identifiers

PMID35079723
PMCPMC8786221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.