Evidence map›Paper›PMID 35079641›Full record

ArticleBiochemistry and biophysics reports2022

NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length.

Tom Rune Karlsen, Maria B Olsen, Xiang Y Kong, Kuan Yang, Ana Quiles-Jiménez, Penelope Kroustallaki, Sverre Holm, Glenn Terje Lines, Pål Aukrust, Tonje Skarpengland and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Research progress on the role of the NEIL family in cancer.Frontiers in cell and developmental biology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Tom Rune KarlsenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Maria B OlsenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Xiang Y KongResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Kuan YangResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Ana Quiles-JiménezResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Penelope KroustallakiDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Sverre HolmResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Glenn Terje LinesSimula Research Laboratory, Oslo, Norway.
Pål AukrustResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Tonje SkarpenglandResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Magnar BjøråsDepartment of Microbiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Tuva B DahlResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Hilde NilsenDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Ida GregersenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Bente HalvorsenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NOSimula Research Laboratory · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deficiency of NEIL3, a DNA repair enzyme, has significant impact on mouse physiology, including vascular biology and gut health, processes related to aging. Leukocyte telomere length (LTL) is suggested as a marker of biological aging, and shortened LTL is associated with increased risk of cardiovascular disease. NEIL3 has been shown to repair DNA damage in telomere regions

Indexed as

HematopoiesisNEIL3SenescenceTelomeres

Identifiers

PMID35079641
PMCPMC8777121
OpenAlexW4206484787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.