ReviewBioengineering & translational medicine2022
Implant-bone-interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo.
Review in Bioengineering & translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed.
- Hierarchical Peptide Functionalized Titania Nanotubes: Improving Stability, Promoting Osteogenesis, and Reducing Infection Risk.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Long-Term Clinical and Radiographic Osseointegration Outcomes of a Highly Porous 3D-Printed Titanium Collar Compared with a Hydroxyapatite-Coated Collar in Megaprostheses.Journal of functional biomaterials · 2026Article
- Alkaline Ozonation-Induced TiOJournal of functional biomaterials · 2026Article
- A Redox Amplification Interface Linking Mitochondrial Dysfunction, Immune-Derived Oxidants, and Biomaterial Electrochemistry in Chronic Inflammation.International journal of molecular sciences · 2026Review
- Toward next-generation hip implants: From failure mechanisms to translational design.Journal of orthopaedic translation · 2026Review
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Controlled EGCG Release from Zeolite-Coated Ti6Al4V: Effects of Divalent Ions on Release and Cytotoxicity.ACS biomaterials science & engineering · 2026Article
- Comparative evaluation of osseointegration among different surface modification techniques in dental implants.Bioinformation · 2026Article
- Article
- Salivary protein adsorption on titanium abutments: a comparative study of edentulous and partially edentulous patients.Frontiers in oral health · 2026Article
- Impact of Laser Surface Modification on Zirconia Implants: A Systematic Review of In Vitro Evidence.Cureus · 2025Review
- Characterization and biocompatibility evaluation of a Ti@HA-GO@IL-4 bioactive composite coating for guided bone regeneration in dental implant applications.BMC oral health · 2025Article
- Micropatterning and Nanodropletting of Titanium by Shifted Surface Laser Texturing Significantly Enhances In Vitro Osteogenesis of Healthy and Osteoporotic Mesenchymal Stromal Cells.Journal of functional biomaterials · 2025Article
- Amino Silane High Positive Charge Layers: A Stable and Durable Alternative Based on Electrostatic Interactions for Titanium Applications, Combining Antimicrobial and Biological Properties.ACS applied bio materials · 2025Article
- Review
- Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.Biological trace element research · 2025Article
- Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap.Bioactive materials · 2025Review
- Antibacterial Polysaccharides in Dental Implantology.Marine drugs · 2025Review
- Controlling Sodium Titanate Crystal Size to Improve Wettability and Early Osseointegration of Titanium Implants: Insights from an Animal Model.Journal of functional biomaterials · 2025Article
- Functional Assessment of Microplasma-Sprayed Hydroxyapatite-Zirconium Bilayer Coatings: Mechanical and Biological Perspectives.Materials (Basel, Switzerland) · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium is commonly and successfully used in dental and orthopedic implants. However, patients still have to face the risk of implant failure due to various reasons, such as implant loosening or infection. The risk of implant loosening can be countered by optimizing the osteointegration capacity of implant materials. Implant surface modifications for structuring, roughening and biological activation in favor for osteogenic differentiation have been vastly studied. A key factor for a successful stable long-term integration is the initial cellular response to the implant material. Hence, cell-material interactions, which are dependent on the surface parameters, need to be considered in the implant design. Therefore, this review starts with an introduction to the basics of cell-material interactions as well as common surface modification techniques. Afterwards, recent research on the impact of osteogenic processes in vitro and vivo provoked by various surface modifications is reviewed and discussed, in order to give an update on currently applied and developing implant modification techniques for enhancing osteointegration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.