Evidence map›Paper›PMID 35079126›Full record

ReviewMolecular psychiatry2022

Putting the "mental" back in "mental disorders": a perspective from research on fear and anxiety.

Vincent Taschereau-Dumouchel, Matthias Michel, Hakwan Lau, Stefan G Hofmann, Joseph E LeDoux

Abstract readReview
In one paragraph

Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. iScience · 2026
    Article
  7. Exploring the network structure and lived experiences of preoperative fear in patients with esophageal cancer: a convergent mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Article
  9. Ecologically-Valid Emotion Signatures Enhance Mood Disorder Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda.Clinical psychological science : a journal of the Association for Psychological Science · 2025
    Article
  19. Transition ability to safe states reduces fear responses to height.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vincent Taschereau-DumouchelDepartment of Psychiatry and Addictology, Université de Montréal, Montreal, Canada. vincent.taschereau-dumouchel@umontreal.ca.ORCID http://orcid.org/0000-0002-9245-7934
Matthias MichelDepartment of Philosophy, New York University, New York, NY, 1003, USA.ORCID http://orcid.org/0000-0002-5780-5702
Hakwan LauRIKEN Center for Brain Science, Wako, Japan.ORCID http://orcid.org/0000-0001-8433-4232
Stefan G HofmannDepartment of Clinical Psychology, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-3548-9681
Joseph E LeDouxCenter for Neural Science and Department of Psychology, New York University, New York, NY, 1003, USA.ORCID http://orcid.org/0000-0001-8518-132X

Funding

Connectomes Related to Anxiety and Depression in AdolescentsU01MH108168 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIELI, JOHN, WHITFIELD-GABRIELI, SUSAN · 2015 to 2019
$4.6M
Treating Phobia with Multivoxel Neuro-reinforcementR61MH113772 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2018 to 2019
$932k
NIMH NIH HHS R61 MH113772NIMH NIH HHS U01 MH108168
6 · The paper itself

Abstract

Mental health problems often involve clusters of symptoms that include subjective (conscious) experiences as well as behavioral and/or physiological responses. Because the bodily responses are readily measured objectively, these have come to be emphasized when developing treatments and assessing their effectiveness. On the other hand, the subjective experience of the patient reported during a clinical interview is often viewed as a weak correlate of psychopathology. To the extent that subjective symptoms are related to the underlying problem, it is often assumed that they will be taken care of if the more objective behavioral and physiological symptoms are properly treated. Decades of research on anxiety disorders, however, show that behavioral and physiological symptoms do not correlate as strongly with subjective experiences as is typically assumed. Further, the treatments developed using more objective symptoms as a marker of psychopathology have mostly been disappointing in effectiveness. Given that "mental" disorders are named for, and defined by, their subjective mental qualities, it is perhaps not surprising, in retrospect, that treatments that have sidelined mental qualities have not been especially effective. These negative attitudes about subjective experience took root in psychiatry and allied fields decades ago when there were few avenues for scientifically studying subjective experience. Today, however, cognitive neuroscience research on consciousness is thriving, and offers a viable and novel scientific approach that could help achieve a deeper understanding of mental disorders and their treatment.

Indexed as

Mental DisordersAnxietyAnxiety DisordersFearHumansPsychopathology

Identifiers

PMID35079126
PMCPMC9095479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.