ArticleScientific reports2022
Interactions between human milk oligosaccharides, microbiota and immune factors in milk of women with and without mastitis.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05794945 (OPTIMISTOptimizing Mastitis Identification and Treatment), which is not on this map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
OPTIMISTOptimizing Mastitis Identification and Treatment
Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Decoding the HMO‒microbiome axis: bridging maternal milk to infant health outcomes.Gut microbes · 2026Review
- Non-pharmacological interventions for lactational mastitis: a systematic review and meta-analysis protocol.BMJ open · 2026Article
- Targeting the Gut-Mammary Axis for Understanding Mastitis Pathogenesis and Therapeutic Strategies.Veterinary sciences · 2025Review
- Genotypic and phenotypic characterization ofmSystems · 2025Article
- Factors Associated with Anthropometry Z-Scores in Exclusively Breastfed Infants Aged 0-6 Months in 10 Cities of China.Nutrients · 2025Article
- Postpartum Maternal Stress is Unrelated to the Infant Fecal Microbiome, but is Associated With the Human Milk Microbiome in Exclusively Breastfeeding Mother-Infant Dyads: The Mother-Infant Microbiomes, Behavior, and Ecology Study (MIMBES).American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications.World journal of microbiology & biotechnology · 2025Review
- The human milk bacteriome and mycobiome and their inter-kingdom interactions viewed across geography.Frontiers in nutrition · 2025Article
- Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome.Cell genomics · 2024Article
- Impacts of Different Perinatal Factors on Faecal Immune Compounds in Infants: Determination of Normal Values.International journal of molecular sciences · 2024Article
- Immunological composition of human milk before and during subclinical and clinical mastitis.Frontiers in immunology · 2024Article
- Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study.American journal of human biology : the official journal of the Human Biology Council · 2023Article
- Article
- Integrated analysis of inflammatory mRNAs, miRNAs, and lncRNAs elucidates the molecular interactome behind bovine mastitis.Scientific reports · 2023Article
- Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.Microbiology spectrum · 2023Article
- Structure of co-expression networks ofFrontiers in molecular biosciences · 2023Article
- Recent advances on human milk oligosaccharide antimicrobial activity.Current opinion in chemical biology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactational mastitis is an excellent target to study possible interactions between HMOs, immune factors and milk microbiota due to the infectious and inflammatory nature of this condition. In this work, microbiological, immunological and HMO profiles of milk samples from women with (MW) or without (HW) mastitis were compared. Secretor status in women (based on HMO profile) was not associated to mastitis. DFLNH, LNFP II and LSTb concentrations in milk were higher in samples from HW than from MW among Secretor women. Milk from HW was characterized by a low bacterial load (dominated by Staphylococcus epidermidis and streptococci), high prevalence of IL10 and IL13, and low sialylated HMO concentration. In contrast, high levels of staphylococci, streptococci, IFNγ and IL12 characterized milk from MW. A comparison between subacute (SAM) and acute (AM) mastitis cases revealed differences related to the etiological agent (S. epidermidis in SAM; Staphylococcus aureus in AM), milk immunological profile (high content of IL10 and IL13 in SAM and IL2 in AM) and milk HMOs profile (high content of 3FL in SAM and of LNT, LNnT, and LSTc in AM). These results suggest that microbiological, immunological and HMOs profiles of milk are related to mammary health of women.
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