Evidence map›Paper›PMID 35078943›Full record

ArticleNeurology2022

Revise the Uniform Determination of Death Act to Align the Law With Practice Through Neurorespiratory Criteria.

Adam Omelianchuk, James Bernat, Arthur Caplan, David Greer, Christos Lazaridis, Ariane Lewis, Thaddeus Pope, Lainie Friedman Ross, David Magnus

Erratum issuedAbstract read
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Diagnostic test accuracy for cessation of circulation during death determination: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Article
  6. Addressing the Problem of Brain Death Misdiagnosis.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Infratentorial brain injury and death by neurologic criteria in Canada: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Review
  14. Answering global challenges to the determination of death: consensus-building leadership from Canada.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Adam OmelianchukFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
James BernatFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
Arthur CaplanFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
David GreerFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
Christos LazaridisFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
Ariane LewisFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
Thaddeus PopeFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
Lainie Friedman RossFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL.
David MagnusFrom the Stanford Center for Biomedical Ethics (A.O., D.M.), CA; Dartmouth Geisel School of Medicine (J.B.), Hanover, NH; NYU Grossman School of Medicine (A.C.), New York; Boston University School of Medicine (D.G.), MA; University of Chicago Medical Center (C.L.), IL; NYU Langone Medical Center (A.L.), New York; Mitchell Hamline School of Law (T.P.), St. Paul, MN; Institute for Translational Medicine (L.F.R.), Chicago; and University of Chicago (L.F.R.), IL. dmagnus@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the Uniform Determination of Death Act (UDDA) has served as a model statute for 40 years, there is a growing recognition that the law must be updated. One issue being considered by the Uniform Law Commission's Drafting Committee to revise the UDDA is whether the text "all functions of the entire brain, including the brainstem" should be changed. Some argue that the absence of diabetes insipidus indicates that some brain functioning continues in many individuals who otherwise meet the "accepted medical standards" like the American Academy of Neurology's. The concern is that the legal criteria and the medical standards used to determine death by neurologic criteria are not aligned. We argue for the revision of the UDDA to more accurately specify legal criteria that align with the medical standards: brain injury leading to permanent loss of the capacity for consciousness, the ability to breathe spontaneously, and brainstem reflexes. We term these criteria neurorespiratory criteria and show that they are well-supported in the literature for physiologic and social reasons justifying their use in the law.

Indexed as

BrainBrain DeathBrain StemConsciousnessHumansUnited States

Identifiers

PMID35078943
PMCPMC8967425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.