Evidence map›Paper›PMID 35078920›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer.

Suresh V Kuchipudi, Meera Surendran-Nair, Rachel M Ruden, Michele Yon, Ruth H Nissly, Kurt J Vandegrift, Rahul K Nelli, Lingling Li, Bhushan M Jayarao, Costas D Maranas and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 1 pooled it
33.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 1 synthesis or guideline pooled it, 257 citations in OpenAlex.

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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Suresh V KuchipudiAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802; skuchipudi@psu.edu vkapur@psu.edu.
Meera Surendran-NairAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0003-4686-8414
Rachel M RudenWildlife Bureau, Iowa Department of Natural Resources, Des Moines, IA 50319.ORCID 0000-0003-3764-9447
Michele YonAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.
Ruth H NisslyAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0002-3102-7447
Kurt J VandegriftThe Center for Infectious Disease Dynamics, Department of Biology and Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802.
Rahul K NelliDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.ORCID 0000-0001-8765-0943
Lingling LiAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.
Bhushan M JayaraoAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.
Costas D MaranasDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802.
Nicole LevineHuck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802.
Katriina WillgertDisease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom.ORCID 0000-0003-3586-1997
Andrew J K ConlanDisease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom.ORCID 0000-0002-2593-6353
Randall J OlsenLaboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030.
James J DavisUniversity of Chicago Consortium for Advanced Science and Engineering, University of Chicago and Division of Data Science and Learning, Argonne National Laboratory, Lemont, IL 60439.
James M MusserLaboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030.ORCID 0000-0002-7765-4956
Peter J HudsonThe Center for Infectious Disease Dynamics, Department of Biology and Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0003-0468-3403
Vivek KapurHuck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802; skuchipudi@psu.edu vkapur@psu.edu.ORCID 0000-0002-9648-0138
Pennsylvania State University · USHouston Methodist · USIowa State University · USUniversity of Cambridge · GBArgonne National Laboratory · US

Funding

BIOINFORMATICS RESOURCE CENTERS FOR INFECTIOUS DISEASES: SARS-CoV-2 ACTIVITIES75N93019C00076 · NIAID · UNIVERSITY OF CHICAGO · PI STEVENS, RICK · 2019 to 2023
$32.6M
NIAID NIH HHS 75N93019C00076
6 · The paper itself

Abstract

Many animal species are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and could act as reservoirs; however, transmission in free-living animals has not been documented. White-tailed deer, the predominant cervid in North America, are susceptible to SARS-CoV-2 infection, and experimentally infected fawns can transmit the virus. To test the hypothesis that SARS-CoV-2 is circulating in deer, 283 retropharyngeal lymph node (RPLN) samples collected from 151 free-living and 132 captive deer in Iowa from April 2020 through January of 2021 were assayed for the presence of SARS-CoV-2 RNA. Ninety-four of the 283 (33.2%) deer samples were positive for SARS-CoV-2 RNA as assessed by RT-PCR. Notably, following the November 2020 peak of human cases in Iowa, and coinciding with the onset of winter and the peak deer hunting season, SARS-CoV-2 RNA was detected in 80 of 97 (82.5%) RPLN samples collected over a 7-wk period. Whole genome sequencing of all 94 positive RPLN samples identified 12 SARS-CoV-2 lineages, with B.1.2 (

Indexed as

AnimalsCOVID-19DeerDisease ReservoirsHumansSARS-CoV-2Zoonosesanimal reservoirdeerOne HealthSARS-CoV-2spillover

Identifiers

PMID35078920
PMCPMC8833191
OpenAlexW4210613328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.