Evidence map›Paper›PMID 35078810›Full record

ArticleBMJ global health2022

Mitigating the effects of COVID-19 on HIV treatment and care in Lusaka, Zambia: a before-after cohort study using mixed effects regression.

Jake M Pry, Kombatende Sikombe, Aaloke Mody, Shilpa Iyer, Jacob Mutale, Natalie Vlahakis, Theodora Savory, Mwanza Wa Mwanza, Keith Mweebo, Annie Mwila and 8 more

Abstract read
In one paragraph

Article in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. COVID-19 impacts on healthcare access in sub-Saharan Africa: an overview.The journal of venomous animals and toxins including tropical diseases · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jake M Pry *Centre for Infectious Disease Research in Zambia, Lusaka, Zambia jmpry@ucdavis.edu.ORCID 0000-0001-6312-4420
Kombatende Sikombe *Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.ORCID 0000-0002-8187-8661
Aaloke ModyDepartment of Internal Medicine, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA.
Shilpa IyerCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Jacob MutaleCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Natalie VlahakisCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Theodora SavoryCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Mwanza Wa MwanzaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Keith MweeboDivision of Global HIV & Tuberculosis, Centers for Disease Control and Prevention, Lusaka, Zambia.
Annie MwilaDivision of Global HIV & Tuberculosis, Centers for Disease Control and Prevention, Lusaka, Zambia.
Consity MwaleZambia Ministry of Health, Lusaka, Zambia.
Mpande Mukumbwa-MwenechanyaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Andrew D KerkhoffUniversity of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-5023-6658
Izukanji SikazweCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Carolyn Bolton MooreCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Daniel MwambaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Elvin H GengDepartment of Internal Medicine, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA.
Michael E HerceCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.

Funding

Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
MENTORING MULTIDISCIPLINARY PATIENT-ORIENTED RESEARCH IN ENGAGEMENT IN HIV CAREK24AI134413 · NIAID · WASHINGTON UNIVERSITY · PI Elvin H. Geng · 2017 to 2026
$1.4M
NIAID NIH HHS K24 AI134413NIAID NIH HHS T32 AI060530
6 · The paper itself

Abstract

introductionThe Zambian Ministry of Health (MoH) issued COVID-19 mitigation guidance for HIV care immediately after the first COVID-19 case was confirmed in Zambia on 18 March 2020. The Centre for Infectious Disease Research in Zambia implemented MoH guidance by: 1) extending antiretroviral therapy (ART) refill duration to 6 multi-month dispensation (6MMD) and 2) task-shifting communication and mobilisation of those in HIV care to collect their next ART refill early. We assessed the impact of COVID-19 mitigation guidance on HIV care 3 months before and after guidance implementation.

methodsWe reviewed all ART pharmacy visit data in the national HIV medical record for PLHIV in care having ≥1 visit between 1 January-30 June 2020 at 59 HIV care facilities in Lusaka Province, Zambia. We undertook a before-after evaluation using mixed-effects Poisson regression to examine predictors and marginal probability of early clinic return (pharmacy visit >7 days before next appointment), proportion of late visit (>7 days late for next appointment) and probability of receiving a 6MMD ART refill.

resultsA total of 101 371 individuals (64% female, median age 39) with 130 486 pharmacy visits were included in the analysis. We observed a significant increase in the adjusted prevalence ratio (4.63; 95% CI 4.45 to 4.82) of early return before compared with after guidance implementation. Receipt of 6MMD increased from a weekly mean of 47.9% (95% CI 46.6% to 49.2%) before to 73.4% (95% CI 72.0% to 74.9%) after guidance implementation. The proportion of late visits (8-89 days late) was significantly higher before (18.8%, 95% CI17.2%to20.2%) compared with after (15.1%, 95% CI13.8%to16.4%) guidance implementation .

conclusionsTimely issuance and implementation of COVID-19 mitigation guidance involving task-shifted patient communication and mobilisation alongside 6MMD significantly increased early return to ART clinic, potentially reducing interruptions in HIV care during a global public health emergency.

Indexed as

COVID-19HIV InfectionsAdultCohort StudiesFemaleHumansMaleSARS-CoV-2Zambiacohort studyCOVID-19epidemiologyHIV

Identifiers

PMID35078810
PMCPMC8795923

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.