Evidence map›Paper›PMID 35078807›Full record

ArticleeNeuro

Dorsal Raphe 5-HT Neurons Utilize, But Do Not Generate, Negative Aversive Prediction Errors.

Rachel A Walker, Rebecca L Suthard, Taylor N Perison, Nora M Sheehan, Caitlin C Dwyer, Jillian K Lee, Eghosa K Enabulele, Madelyn H Ray, Michael A McDannald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Striatal Serotonin Release Signals Reward Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rachel A WalkerDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467 rachel.a.zacharias@gmail.com michael.mcdannald@bc.edu.
Rebecca L SuthardDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Taylor N PerisonDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Nora M SheehanDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Caitlin C DwyerDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Jillian K LeeDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Eghosa K EnabuleleDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Madelyn H RayDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467.
Michael A McDannaldDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467 rachel.a.zacharias@gmail.com michael.mcdannald@bc.edu.ORCID 0000-0001-8525-1260
Boston College · US

Funding

Early life stress, neuron-type function and a raphe-amygdala circuit for threat estimationR01MH117791 · NIMH · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2018 to 2025
$4.0M
Neural encoding of reward and safetyR00DA034010 · NIDA · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2014 to 2016
$727k
NIDA NIH HHS R00 DA034010NIMH NIH HHS R01 MH117791
6 · The paper itself

Abstract

The dorsal raphe nucleus (DRN) contains the largest population of serotonin (5-HT) neurons in the central nervous system. 5-HT, synthesized via tryptophan hydroxylase 2 (Tph2), is a widely functioning neuromodulator implicated in fear learning. Here, we sought to investigate whether DRN 5-HT is necessary to reduce fear via negative prediction error (-PE). Using male and female TPH2-cre rats, DRN

Indexed as

Dorsal Raphe NucleusSerotoninAnimalsFemaleHumansMaleNeuronsOptogeneticsRatsTryptophan HydroxylaseSerotoninTryptophan Hydroxylasediscriminationextinctionfearprediction errorserotoninTph2-cre

Identifiers

PMID35078807
PMCPMC8868025
OpenAlexW4207077327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.