SynthesisArchives of disease in childhood. Fetal and neonatal edition2022
MRI-based brain volumes of preterm infants at term: a systematic review and meta-analysis.
Synthesis in Archives of disease in childhood. Fetal and neonatal edition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Magnetic Resonance Imaging of the Neonatal Brain: Modalities, Scoring Systems, and Clinical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Quantitative measures of autonomic cardiorespiratory maturation in preterm infants are associated with brain volumes at term age.Early human development · 2026Article
- Neurodevelopmental Outcome in Very Low Birth Weight Preterm Infants: An Exploratory Multivariable Analysis Including Sonographic Brain Volume Trajectories-Data from the NeoNEVS Project.Children (Basel, Switzerland) · 2026Article
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 3: Impacts on Growth, Neurodevelopment & Nutrition.Children (Basel, Switzerland) · 2026Review
- Postmenstrual age-adjusted brain volumes and their association with early neurodevelopmental outcomes in very low birth weight infants.Scientific reports · 2026Article
- Aperiodic parameters of the fMRI power spectrum associate with preterm birth and neonatal age.Communications biology · 2026Article
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
- Harmonization of slice thickness through resampling improves comparability of MRI-derived neonatal brain volumes.Frontiers in radiology · 2026Article
- SEPoolConvNeXt: A Deep Learning Framework for Automated Classification of Neonatal Brain Development Using T1- and T2-Weighted MRI.Journal of clinical medicine · 2025Article
- A Physiologically Based Modeling Approach to Evaluate Intravenous Levetiracetam Dosing in Term and Preterm Neonates.Journal of clinical pharmacology · 2025Article
- Trends in Term-Equivalent Age Brain Volumes in Infants Born Across the Gestational Age Spectrum.Children (Basel, Switzerland) · 2025Article
- Development and Validation of an MRI-Based Brain Volumetry Model Predicting Poor Psychomotor Outcomes in Preterm Neonates.Journal of clinical medicine · 2025Article
- Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injury.Journal of neuroinflammation · 2025Article
- Brain volumes and cortical thickness and associations with cognition in children born extremely preterm.Pediatric research · 2025Article
- Convolutional neural network (CNN) configuration using a learning automaton model for neonatal brain image segmentation.PloS one · 2025Article
- Brain volumes are related with motor skills at late childhood in children born extremely preterm.PloS one · 2025Article
- Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants.Pediatric radiology · 2024Article
- Global trends in neonatal MRI brain neuroimaging research over the last decade: a bibliometric analysis.Quantitative imaging in medicine and surgery · 2024Article
- Impact of Nutritional Status on Total Brain Tissue Volumes in Preterm Infants.Children (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMRI allows a detailed assessment of brain structures in preterm infants, outperforming cranial ultrasound. Neonatal MR-based brain volumes of preterm infants could serve as objective, quantitative and reproducible surrogate parameters of early brain development. To date, there are no reference values for preterm infants' brain volumes at term-equivalent age.
objectiveSystematic review of the literature to determine reference ranges for MRI-based brain volumes of very preterm infants at term-equivalent age.
methodsPubMed Database was searched on 6 April 2020 for studies reporting MR-based brain volumes on representative unselected populations of very preterm and/or very low birthweight infants examined at term equivalent age (defined as 37-42 weeks mean postmenstrual age at MRI). Analyses were limited to volumetric parameters reported in >3 studies. Weighted mean volumes and SD were both calculated and simulated for each parameter.
resultsAn initial 367 publications were identified. Following application of exclusion criteria, 13 studies from eight countries were included for analysis, yielding four parameters. Weighted mean total brain volume was 379 mL (SD 72 mL; based on n=756). Cerebellar volume was 21 mL (6 mL; n=791), cortical grey matter volume 140 mL (47 mL; n=572) and weighted mean volume of unmyelinated white matter was 195 mL (38 mL; n=499).
conclusionThis meta-analysis reports pooled data on several brain and cerebellar volumes which can serve as reference for future studies assessing MR-based volumetric parameters as a surrogate outcome for neurodevelopment and for the interpretation of individual or cohort MRI-based volumetric findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.