Evidence map›Paper›PMID 35078617›Full record

ArticleInjury2022

A bioactive synthetic membrane improves bone healing in a preclinical nonunion model.

Malcolm R DeBaun, Brett P Salazar, Yan Bai, Michael J Gardner, Yunzhi Peter Yang, Stanford iTEAM group, Chi-Chun Pan, Alex Martin Stahl, Seydesina Moeinzadeh, Sungwoo Kim and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Injury, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Malcolm R DeBaunDepartment of Orthopaedic Surgery, Duke University, NC, USA.
Brett P SalazarDepartment of Orthopaedic Surgery, Stanford University, CA, USA.
Yan BaiDepartment of Orthopaedic Surgery, Stanford University, CA, USA; School of Pharmacy, Chongqing Medical University, Chongqing, China.
Michael J GardnerDepartment of Orthopaedic Surgery, Stanford University, CA, USA. Electronic address: michaelgardner@stanford.edu.
Yunzhi Peter YangDepartment of Orthopaedic Surgery, Stanford University, CA, USA; Department of Mechanical Engineering, Stanford University, CA, USA; Department of Bioengineering, Stanford University, CA, USA. Electronic address: ypyang@stanford.edu.
Stanford iTEAM groupDepartment of Orthopaedic Surgery, Stanford University, CA, USA.
Chi-Chun PanDepartment of Orthopaedic Surgery, Stanford University, CA, USA; Department of Mechanical Engineering, Stanford University, CA, USA.
Alex Martin StahlDepartment of Chemistry, Stanford University, CA, USA.
Seydesina MoeinzadehDepartment of Orthopaedic Surgery, Stanford University, CA, USA.
Sungwoo KimDepartment of Orthopaedic Surgery, Stanford University, CA, USA.
Elaine LuiDepartment of Orthopaedic Surgery, Stanford University, CA, USA; Department of Mechanical Engineering, Stanford University, CA, USA.
Carolyn KimDepartment of Orthopaedic Surgery, Stanford University, CA, USA; Department of Mechanical Engineering, Stanford University, CA, USA.
Sien LinDepartment of Orthopaedic Surgery, Stanford University, CA, USA.
L Henry GoodnoughDepartment of Orthopaedic Surgery, Stanford University, CA, USA.
Harsh WadhwaDepartment of Orthopaedic Surgery, Stanford University, CA, USA.

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
Systems Modeling Guided Bone regenerationU01AR069395 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YANG, YUNZHI, ZHOU, XIAOBO · 2016 to 2021
$3.4M
Tissue Engineering Approaches for Improved Treatment of Early Stage Osteonecrosis of the HipR01AR072613 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B, YANG, YUNZHI · 2018 to 2022
$2.2M
Vascularization in bone tissue engineering constructsR01AR074458 · NIAMS · STANFORD UNIVERSITY · PI YANG, YUNZHI · 2019 to 2023
$1.7M
NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R01 AR072613NIAMS NIH HHS R01 AR074458NIAMS NIH HHS U01 AR069395
6 · The paper itself

Abstract

objectivesHigh energy long bone fractures with critical bone loss are at risk for nonunion without strategic intervention. We hypothesize that a synthetic membrane implanted at a single stage improves bone healing in a preclinical nonunion model.

methodsUsing standard laboratory techniques, microspheres encapsulating bone morphogenic protein-2 (BMP2) or platelet derived growth factor (PDGF) were designed and coupled to a type 1 collagen sheet. Critical femoral defects were created in rats and stabilized by locked retrograde intramedullary nailing. The negative control group had an empty defect. The induced membrane group (positive control) had a polymethylmethacrylate spacer inserted into the defect for four weeks and replaced with a bare polycaprolactone/beta-tricalcium phosphate (PCL/β-TCP) scaffold at a second stage. For the experimental groups, a bioactive synthetic membrane embedded with BMP2, PDGF or both enveloped a PCL/β-TCP scaffold was implanted in a single stage. Serial radiographs were taken at 1, 4, 8, and 12 weeks postoperatively from the definitive procedure and evaluated by two blinded observers using a previously described scoring system to judge union as primary outcome.

resultsAll experimental groups demonstrated better union than the negative control (p = 0.01). The groups with BMP2 incorporated into the membrane demonstrated higher average union scores than the other groups (p = 0.01). The induced membrane group performed similarly to the PDGF group. Complete union was only demonstrated in groups with BMP2-eluting membranes.

conclusionsA synthetic membrane comprised of type 1 collagen embedded with controlled release BMP2 improved union of critical bone defects in a preclinical nonunion model.

Indexed as

Calcium PhosphatesFracture Fixation, IntramedullaryAnimalsFemurHumansPolymethyl MethacrylateRatsCalcium PhosphatesPolymethyl Methacrylate

Identifiers

PMID35078617
PMCPMC8940692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.