Evidence map›Paper›PMID 35078612›Full record

ReviewHandbook of clinical neurology2022

Clinical and neuroimaging characteristics of primary progressive aphasia.

Donna C Tippett, Zafer Keser

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Handbook of clinical neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Non-fluent agrammatic variant of primary progressive aphasia in a bilingual Mandarin/English speaker: a case report.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
    Article
  5. Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer's disease-related primary progressive aphasia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  6. The Quebec Semantic Memory Battery: Development, Standardization, and Psychometric Assessment of a Semantic Memory Battery in French.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  7. Clinical application of MAO-B PET usingGeriatrics & gerontology international · 2024
    Review
  8. The Semantic Association Test (SAT): normative data from healthy Italian participants and a validation study in aphasic patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Donna C TippettDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: dtippet1@jhmi.edu.
Zafer KeserDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Funding

Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021
$6.4M
NIDCD NIH HHS R01 DC011317
6 · The paper itself

Abstract

The chapter covers the clinical syndrome of a primary progressive aphasia (PPA), the demographics of this rare neurodegenerative disease, defining clinical and neuroanatomic characteristics of each PPA variant, disease progression, and behavioral features. The chapter begins with a brief introduction that includes references to seminal papers that defined this clinical syndrome and its three variants. The classic PPA subtypes discussed in the chapter are semantic variant PPA (svPPA), nonfluent/agrammatic PPA (nfaPPA), and logopenic variant PPA (lvPPA). The key language and cognitive characteristics, and language tasks that can elicit these language impairments, are detailed. Overlap in the clinical profiles of the PPA variants, which make differential diagnosis challenging, are explained. Disease progression is described, revealing that the PPA variants become more similar over time. Although PPA is language-predominant dementia, there are behavioral manifestations, particularly in svPPA. Changes in behavior in this variant are addressed as well as behavioral changes in nfaPPA and lvPPA that are less well recognized. The patterns of atrophy in the left temporal, parietal, and/or frontal cortices unique to each PPA variant are described. The underlying neuropathologies of the PPA variants are discussed, specifically tauopathies and non-tauopathies associated with svPPA and nfaPPA and Alzheimer's disease pathology in lvPPA.

Indexed as

Alzheimer DiseaseAphasia, Primary ProgressiveNeurodegenerative DiseasesHumansLanguageNeuroimagingLanguageLogopenic variant primary progressive aphasiaNeurodegenerativeNeuroimagingNonfluent agrammatic primary progressive aphasiaPrimary progressive aphasiaSemantic variant primary progressive aphasia

Identifiers

PMID35078612
PMCPMC9951770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.