Evidence map›Paper›PMID 35078545›Full record

ArticlePalliative & supportive care2022

Virtual reality for improving pain and pain-related symptoms in patients with advanced stage colorectal cancer: A pilot trial to test feasibility and acceptability.

Sarah A Kelleher, Hannah M Fisher, Joseph G Winger, Shannon N Miller, Grace H Amaden, Tamara J Somers, Luana Colloca, Hope E Uronis, Francis J Keefe

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Palliative & supportive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
17.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06248216 narecruitingnot on this mapstarted 2024, after this paper: background citation

Implementation of an At-Home Multimodal Integrative Therapy Via Virtual Reality for Patients With Cancer-Treatment Associated Symptoms

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2024 to 2027Enrolled30ConditionsCancer, Cancer Pain, Virtual RealityArmsRelievrx, Audio Mp4
NCT07053228 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

e-Natureza Blue Care - Impact of Virtual Reality on Pain Perception, Mood States, and Analgesic Use in Patients With Cancer Pain: Randomized Clinical Trial.

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2025 to 2026Enrolled130ConditionsCancer Pain, Palliative CareArmsNature-based virtual reality, Standard Pain Management
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Application of virtual reality for supportive care in cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Virtual reality for outpatient management of cancer pain: a pilot dosing study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  12. Article
  13. Virtual Reality Interventions and Chronic Pain: Scoping Review.Journal of medical Internet research · 2025
    Article
  14. Review
  15. Experience of breast cancer patients participating in a virtual reality psychological rehabilitation: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  16. Review
  17. Article
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  19. Virtual reality technology for pain management in advanced cancer.The Cochrane database of systematic reviews · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sarah A KelleherDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.ORCID 0000-0002-0668-6803
Hannah M FisherDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Joseph G WingerDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.ORCID 0000-0001-6278-2560
Shannon N MillerDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Grace H AmadenDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Tamara J SomersDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Luana CollocaDepartment of Pain and Translational Symptom Science, School of Nursing and Department of Anesthesiology School of Medicine, University of Maryland, Baltimore, MD.
Hope E UronisDepartment of Internal Medicine, Duke University Medical Center, Duke Cancer Institute, Durham, NC.
Francis J KeefeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Duke Medical Center · USUniversity of Maryland, Baltimore · US

Funding

Refinement and Expansion of the Palliative Care Research Cooperative Group (PCRC)U24NR014637 · NINR · DUKE UNIVERSITY · PI KUTNER, JEAN S, POLLAK, KATHRYN I · 2013 to 2017
$9.6M
Palliative Care Research Cooperative Group (PCRC): Refinement and ExpansionU2CNR014637 · NINR · UNIVERSITY OF COLORADO DENVER · PI COLBORN, KATHRYN LOUISE · 2018 to 2022
$8.6M
NINR NIH HHS U24 NR014637NINR NIH HHS U2C NR014637
6 · The paper itself

Abstract

objectiveVirtual reality (VR) has the potential to improve pain and pain-related symptoms. We examined the feasibility, acceptability, safety, and impact of a 30-min virtual underwater/sea environment (VR Blue) for reducing pain and pain-related symptoms in advanced colorectal cancer patients. A qualitative exit interview was conducted to understand preferences, thoughts, and feelings about the VR session.

methodParticipants (

resultsAll participants (100%) completed the VR Blue session. There was 100% data collection at the pre- and post-assessments. Satisfaction with VR Blue was high SIGNIFICANCE OF

resultsThis work supports the feasibility, acceptability, and safety of VR Blue for advanced colorectal cancer patients. Participants showed significant pre-post improvement in pain and pain-related symptoms hinting to the potential feasibility of VR interventions in this population. Larger, randomized trials with a control condition are needed to examine the efficacy of VR-based interventions for patients with advanced colorectal cancer and pain.

Indexed as

Colorectal NeoplasmsVirtual RealityFeasibility StudiesHumansPainPilot ProjectsAdvanced diseaseCancer painColorectal cancerPalliative careVirtual reality

Identifiers

PMID35078545
PMCPMC9314453
OpenAlexW4210384340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.