Evidence map›Paper›PMID 35078521›Full record

ArticleJournal of medical case reports2022

Left supraclavicular (Virchow's) node metastasis detected before primary infradiaphragmatic tumor: a case series.

Yumi Mochizuki, Maiko Tsuchiya, Jun Oyama, Akane Wada, Takuma Kugimoto, Takeshi Kuroshima, Hideaki Hirai, Hirofumi Tomioka, Hiroyuki Harada, Tohru Ikeda and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yumi MochizukiDepartment of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. mochizuki.osur@tmd.ac.jp.
Maiko TsuchiyaDepartment of Oral Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Jun OyamaDepartment of Nuclear Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Akane WadaDepartment of Oral Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Takuma KugimotoDepartment of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Takeshi KuroshimaDepartment of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Hideaki HiraiDepartment of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Hirofumi TomiokaDepartment of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Hiroyuki HaradaDepartment of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Tohru IkedaDepartment of Oral Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Takumi AkashiDivision of Diagnostic Radiology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastasis of infradiaphragmatic tumors to the left supraclavicular lymph node is reported to be rare. When metastasis is detected in the left supraclavicular node in patients with head and neck carcinoma, locating the primary cancer remains a difficult and time-consuming challenge despite the dramatic development of screening technologies and treatment methods. CASE PRESENTATION: We report three cases of malignant infradiaphragmatic tumor diagnosed following an initial finding of left supraclavicular node metastasis after surgery for tongue squamous cell carcinoma (follow-up period, range 18-62 months). In these cases, adenocarcinoma was diagnosed based on left supraclavicular node biopsies, and a second primary tumor was found, in a 78-year-old Japanese woman with a diagnosis of cholangiocarcinoma, a 64-year-old Japanese man with a diagnosis of bladder carcinoma, and a 61-year-old Japanese man with a diagnosis of prostate carcinoma. In the cholangiocarcinoma case, carbohydrate antigen 19-9 and alpha-fetoprotein levels helped to diagnose cholangiocarcinoma. Palliative care only was given, with survival for 11 months after diagnosis of lymph node metastasis. In the bladder carcinoma case, pathological analysis of fine-needle aspiration biopsy specimen of the metastatic cervical lymph node showed atypical cells with slight squamous differentiation. Hematoxylin-eosin staining of the bladder lesion did not identify a clear glandular or squamous component, and we could not make a definitive diagnosis of whether the lesion was poorly differentiated squamous cell carcinoma, adenocarcinoma, or high-grade urothelial carcinoma. GATA3 staining aided in the diagnosis of urothelial bladder cancer with left supraclavicular node metastasis. He survived for 2 months after diagnosis of left supraclavicular lymph node metastasis. In the prostate carcinoma case,

conclusionsPathological diagnosis on the basis of immunohistochemistry and specific diagnosis methods such as radiological and serological assessments are important for providing rapid diagnosis and appropriate treatment.

Indexed as

Carcinoma, Squamous CellCarcinoma, Transitional CellTongue NeoplasmsUrinary Bladder NeoplasmsAgedFemaleHumansLymphatic MetastasisMaleMiddle AgedBladder carcinomaIntrahepatic cholangiocarcinomaLeft supraclavicular node metastasisLeft supraclavicular (Virchow’s) nodeOral cancerProstate carcinoma

Identifiers

PMID35078521
PMCPMC8790909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.