ArticleJournal of neurodevelopmental disorders2022
Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder.
Article in Journal of neurodevelopmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity.Autism research : official journal of the International Society for Autism Research · 2026Article
- Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.Autism research : official journal of the International Society for Autism Research · 2026Article
- Vision transformer and complex network analysis for autism spectrum disorder classification in T1 structural MRI.Japanese journal of radiology · 2025Article
- Mapping Resting-State Brain Functional Specialization to Neurotransmitter Profiles in Autism Spectrum Disorder.CNS neuroscience & therapeutics · 2025Article
- A lightweight, end-to-end explainable, and generalized attention-based graph neural network model trained on high-order spatiotemporal organization of dynamic functional connectivity to classify autistics from typically developing.Network neuroscience (Cambridge, Mass.) · 2025Article
- Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- Abnormal multimodal neuroimaging patterns associated with social deficits in male autism spectrum disorder.Human brain mapping · 2024Article
- Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder.BMC sports science, medicine & rehabilitation · 2024Article
- Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder.Frontiers in psychiatry · 2024Review
- Neurobehavioral sex-related differences in Nf1Biology of sex differences · 2023Article
- Adaptive noise depression for functional brain network estimation.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX.
methodsParticipants included 29 adolescents: 15 with ASD and 15 with typical neurodevelopment (TD). They performed the EcoSupermarketX (a shopping simulation with three goal-oriented sub-tasks including "no cue", "non-social" or "social" cues), during neuroimaging and eye-tracking.
resultsASD differed from TD only in total time and distance to complete the "social cue" sub-task with matched eye-tracking measures. Neuroimaging revealed simultaneous hyperactivation across social, executive, and saliency circuits in ASD. In contrast, ASD showed reduced activation in the parahippocampal gyrus, involved in scene recognition.
conclusionsWhen performing a virtual shopping task matching the performance of controls, ASD adolescents hyperactivate three core networks: executive, saliency and social cognition. Parahippocampal hypoactivation is consistent with effortless eidetic scene processing, in line with the notion of peaks and valleys of neural recruitment in individuals with ASD. These hyperactivation/hypoactivation patterns in daily life tasks provide a circuit-level signature of neural diversity in ASD, a possible intervention target.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.