Evidence map›Paper›PMID 35078371›Full record

ArticleCirculation2022

Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association.

Connie W Tsao, Aaron W Aday, Zaid I Almarzooq, Alvaro Alonso, Andrea Z Beaton, Marcio S Bittencourt, Amelia K Boehme, Alfred E Buxton, April P Carson, Yvonne Commodore-Mensah and 30 more

Erratum issued 19 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 19 registered trials, which are not on this map. Cited by 3,042 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3,042citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06675994 not yet recruitingstarted 2024, after this paper: background citation

Evaluation of PCSK9 Enzyme in Non-Cholesterol Biological Pathways: In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme

Ran2024Enrolled80Registered outcomes4Posted comparisons0ConditionsDiabetes, Family History of Cerebrovascular Disease, Family History of Coronary Artery Disease, Family History of Peripheral Artery DiseaseArmsPCSK9 Antibody, PCSK9 Enzyme
Open the trial in the graph
NCT05492513 narecruitingnot on this map

Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment and Deficits in Desired Occupational Performance: A Pilot Study

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2022 to 2027Enrolled12ConditionsCVA (Cerebrovascular Accident), Stroke, Upper Extremity ParesisArmsGrade 1 CI Therapy +Sensory Components
NCT05515237 narecruitingnot on this mapstarted 2023, after this paper: background citation

Constraint-Induced Movement Therapy Plus Sensory Components for Adults With Mild-to-Severe Arm and Hand Impairment After Stroke

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2023 to 2027Enrolled15ConditionsCVA (Cerebrovascular Accident), Stroke, Upper Extremity ParesisArmsGrade 2-5 CI Therapy + Sensory Components
NCT05650606 naterminatednot on this mapstarted 2023, after this paper: background citation

Inpatient Rehabilitation and Post-Discharge Outcomes of Patients With Stroke Participating in High Intensity Gait Training

TypeinterventionalSponsorSunnyview Rehabilitation HospitalRan2023 to 2023Enrolled2ConditionsCerebral Vascular AccidentArmsHigh Intensity Gait Training, Conventional Therapy
NCT05711719 phase2completednot on this mapstarted 2023, after this paper: background citation

Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction

TypeinterventionalSponsorJohns Hopkins UniversityRan2023 to 2025Enrolled45ConditionsMetabolic Syndrome, Coronary Microvascular DysfunctionArmsVericiguat, Placebo
NCT05874661 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Focus of Attention on Motor Performance and Learning During a Sit to Stand Task in Individuals Post-stroke

TypeinterventionalSponsorWestern Carolina UniversityRan2023 to 2024Enrolled16ConditionsStroke, AcuteArmsExternal Focus of Attention, Internal Focus of Attention
NCT05907694 narecruitingnot on this mapstarted 2024, after this paper: background citation

Medical Treatment With or Without Transcatheter Patent Foramen Ovale CloSure for Older Patients With CrypTogenic StrOke and Patent Foramen Ovale. The STOP Trial

TypeinterventionalSponsorJosep Rodes-CabauRan2024 to 2037Enrolled714ConditionsPatent Foramen Ovale, Cryptogenic Stroke, Older Patients, Medical TreatmentArmsTranscatheter PFO closure, Optimal medical treatment
NCT06030115 completednot on this map

Effects of a Physical Therapist-driven Individualized Hybrid Model of the Exercise Component of Cardiac Rehabilitation on Patient Outcomes: a Prospective Cohort Study

TypeobservationalSponsorGood Shepherd Integrated Healthcare SystemsRan2019 to 2021Enrolled100ConditionsCardiac Surgery, Coronary Artery Bypass Graft CABG, Stent, Valve ReplacementArmsExercise Component Of Cardiac Rehabilitation (Hybrid Model) Intensity Recovery Progression Protocol (IRPP)
NCT06039059 completednot on this map

Influence of Risk Factors Such as Serum Cholesterol Level on ISR and Nonintervened Coronary Lesions

TypeobservationalSponsorRenJi HospitalRan2020 to 2023Enrolled510ConditionsCoronary Artery Disease, Multi Vessel Coronary Artery Disease
NCT06085248 nacompletednot on this mapstarted 2023, after this paper: background citation

Responders to Metronome-based Rhythmic Auditory Stimulation in Individuals Post-Stroke and Older Adults

TypeinterventionalSponsorBoston University Charles River CampusRan2023 to 2024Enrolled45ConditionsStroke, Old AgeArmsSubject-specific optimized RAS, Active walking
NCT06112418 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Randomized Comparison of Cleerly Coronary Artery Disease Stage-Based Care Versus Risk Factor-Based Care for Primary Prevention of Cardiovascular Events

TypeinterventionalSponsorCleerly, Inc.Ran2024 to 2029Enrolled7,500ConditionsDiabetes Mellitus, Type 2, PreDiabetes, Metabolic SyndromeArmsThe Cleerly CAD Staging System
NCT06136806 unknown statusnot on this mapstarted 2024, after this paper: background citation

Diagnostic Performance of a Novel Ferumoxytol-Enhanced Coronary Magnetic Resonance Angiography/ Venography on Panvascular Disease: a Single-center Clinical Study.

Typeobservational_patient_registrySponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2024 to 2025Enrolled200ConditionsPanvascular DiseaseArmsFerumoxytol Enhanced Magnetic Resonance Angiography( FE-MRA);Coronary/Renal /Lower artery Arteriography, Ferumoxytol Enhanced Magnetic Resonance Venography( FE-MRV), Computed Tomography Pulmonary Angiography, Ultrasound for Lower Extremity Deep Vein.
NCT06600178 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Innovative Therapy to Treat Women With Angina With Nonobstructive Coronary Artery Disease (ANOCA) and Coronary Microvascular Disease

TypeinterventionalSponsorUniversity of VirginiaRan2025 to 2026Enrolled150ConditionsAngina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Disease, Coronary Microvascular Dysfunction (CMD)ArmsBrezavvy 20Mg Oral Tablet, Placebo
NCT06735599 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure

TypeinterventionalSponsorGeorgia State UniversityRan2024 to 2027Enrolled40ConditionsHypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, FemaleArmsWild Blueberry, Placebo
NCT06837181 recruitingnot on this mapstarted 2025, after this paper: background citation

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

TypeobservationalSponsorJaeb Center for Health ResearchRan2025 to 2028Enrolled200ConditionsCystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, RetinopathyArmsobservational study
NCT06945328 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Study of Patients With Drug-induced Non-variceal Upper Gastrointestinal Bleeding

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled100ConditionsUpper Gastrointestinal Bleeding (UGIB)ArmsUpper endoscopy
NCT06947564 completednot on this map

Angiography-derived Index of Microcirculatory Resistance Predicts Microvascular Obstruction and Infarct Size in Patients With ST-segment-elevation Myocardial Infarction

TypeobservationalSponsorRenJi HospitalRan2012 to 2024Enrolled843ConditionsCoronary Artery Disease, STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery DiseaseArmsCMR
NCT07088120 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

PRecision-Controlled Ventilation to Enhance Cardiac Arrest Intervention and Survival IN CPR: A Multi-Center Randomized Controlled Trial

TypeinterventionalSponsorRush University Medical CenterRan2026 to 2030Enrolled852ConditionsCardiac Arrest (CA)ArmsPrecision-Controlled Ventilation with Real-Time Feedback, Standard Manual Ventilation During CPR
NCT07469397 recruitingnot on this mapstarted 2025, after this paper: background citation

Preliminary Exploration of Factors Affecting Complete Hemostasis and Supine Time After Removal of Femoral Arterial Sheath in ICU Patients

TypeobservationalSponsorNational Taiwan University HospitalRan2025 to 2026Enrolled157ConditionsRemoval of Femoral Arterial Sheath in ICU Patients, Complete Hemostasis, Coronary Artery Disease, Percutaneous Coronary InterventionArmsDirect Inspection, medical records browsing
3 · Its place in the literature

Who cites it

3,042 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
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  14. Development of a prospective clinical workflow for proton beam therapy of ventricular tachycardia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  15. Review
  16. Hepatocyte-SpecificAntioxidants (Basel, Switzerland) · 2026
    Article
  17. LncRNA H19 promotes vascular remodeling by inhibiting MFN2.Functional & integrative genomics · 2026
    Article
  18. Article
  19. Article
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2,982 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Connie W Tsao
Aaron W Aday
Zaid I Almarzooq
Alvaro Alonso
Andrea Z Beaton
Marcio S Bittencourt
Amelia K Boehme
Alfred E Buxton
April P Carson
Yvonne Commodore-Mensah
Mitchell S V Elkind
Kelly R Evenson
Chete Eze-Nliam
Jane F Ferguson
Giuliano Generoso
Jennifer E Ho
Rizwan Kalani
Sadiya S Khan
Brett M Kissela
Kristen L Knutson
Deborah A Levine
Tené T Lewis
Junxiu Liu
Matthew Shane Loop
Jun Ma
Michael E Mussolino
Sankar D Navaneethan
Amanda Marma Perak
Remy Poudel
Mary Rezk-Hanna
Gregory A Roth
Emily B Schroeder
Svati H Shah
Evan L Thacker
Lisa B VanWagner
Salim S Virani
Jenifer H Voecks
Nae-Yuh Wang
Kristine Yaffe
Seth S Martin

Funding

The Effect of Lower Blood Pressure over the Life Course on Late-life Cognition in Blacks, Hispanics, and Whites (BP-COG)R01NS102715 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2017 to 2021
$3.8M
The Effect of Vascular Risk Factors on Risk of Alzheimer's Disease and Related Dementias after Stroke (STROKE COG)RF1AG068410 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2020 to 2020
$3.1M
NIA NIH HHS RF1 AG068410
6 · The paper itself

Abstract

backgroundThe American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).

methodsThe American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year's worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year's edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy.

resultsEach of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics.

conclusionsThe Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

Indexed as

ExerciseHealth BehaviorAmerican Heart AssociationHeart DiseasesHumansRisk FactorsStrokeUnited StatesAHA Scientific Statementscardiovascular diseasesepidemiologyrisk factorsstatisticsstroke

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 13 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.