Evidence map›Paper›PMID 35078337›Full record

ArticleJournal of the Royal Society, Interface2022

Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes.

D Chan, G J Won, A T Read, C R Ethier, E Thackaberry, S R Crowell, H Booler, V Bantseev, J M Sivak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Drug Distribution After Intravitreal Injection: A Mathematical Model.Investigative ophthalmology & visual science · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

D ChanDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
G J WonDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
A T ReadWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA.
C R EthierWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA.
E ThackaberrySafety Assessment, Genentech Inc., San Francisco, CA, USA.
S R CrowellPreclinical and Translational Pharmacokinetics and Pharmacodynamics (PTPK) Genentech Inc., San Francisco, CA, USA.
H BoolerSafety Assessment, Genentech Inc., San Francisco, CA, USA.
V BantseevSafety Assessment, Genentech Inc., San Francisco, CA, USA.
J M SivakDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-8776-223X
University of San Francisco · USUniversity Health Network · CAGeorgia Institute of Technology · US

Funding

Homeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin CircuitR01EY030218 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, JOHN G, GRONERT, KARSTEN · 2020 to 2024
$2.4M
CIHRNEI NIH HHS R01 EY030218
6 · The paper itself

Abstract

Intravitreal (ITV) drug delivery is a new cornerstone for retinal therapeutics. Yet, predicting the disposition of formulations in the human eye remains a major translational hurdle. A prominent, but poorly understood, issue in pre-clinical ITV toxicity studies is unintended particle movements to the anterior chamber (AC). These particles can accumulate in the AC to dangerously raise intraocular pressure. Yet, anatomical differences, and the inability to obtain equivalent human data, make investigating this issue extremely challenging. We have developed an organotypic perfusion strategy to re-establish intraocular fluid flow, while maintaining homeostatic pressure and pH. Here, we used this approach with suitably sized microbeads to profile anterior and posterior ITV particle movements in live versus perfused porcine eyes, and in human donor eyes. Small-molecule suspensions were then tested with the system after exhibiting differing behaviours

Indexed as

Pharmaceutical PreparationsRetinaAnimalsHumansIntraocular PressureIntravitreal InjectionsPerfusionSwinePharmaceutical Preparationsdrug deliveryintravitreal drug developmentocular perfusionoutflow facilitypharmacokinetics

Identifiers

PMID35078337
PMCPMC8790337
OpenAlexW4210485387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.