ArticlePlant physiology2022
MdWRKY126 modulates malate accumulation in apple fruit by regulating cytosolic malate dehydrogenase (MdMDH5).
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 79 citations in OpenAlex.
- MdWRKY125 bridges cold condition and fruit flavor by activating the sucrose synthase geneaBIOTECH · 2026Article
- The Transcription Factor PsLBD42 Enhances Drought Tolerance Through Regulating the Fucosyltransferase PsFUT2 to Sustain Root Growth in Poplar.Plant, cell & environment · 2026Article
- Class I TCP transcription factor OsTCP4 suppresses plant height via negatively regulating the green revolution genePlant diversity · 2026Article
- BuildingFood chemistry. Molecular sciences · 2026Article
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
- Integrative Multi-Omics Reveals Quality Markers and Metabolic Pathways Across Genotype and Ripening Gradients in High-AltitudeFoods (Basel, Switzerland) · 2025Article
- Malate accumulation and transcriptome patterns during fruit development in sweet Cherry (Prunus avium L.).BMC plant biology · 2025Article
- Identification of Key Regulators Mediating Gamma-Aminobutyric Acid (GABA) and Organic Acid Accumulation in Strawberry.Plants (Basel, Switzerland) · 2025Article
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- Article
- Recent advances in improving yield and immunity through transcription factor engineering.Journal of integrative plant biology · 2025Review
- Population-level gene copy number variations reveal distinct genetic properties of different Malus species.BMC genomics · 2025Article
- Multidimensional Transcriptomics Reveals the Key Genes and Pathways Regulating the Acidity of Apples.Current issues in molecular biology · 2025Article
- The MADS-Box Transcription Factor EjAGL18 Negatively Regulates Malic Acid Content in Loquat by RepressingInternational journal of molecular sciences · 2025Article
- Pre-harvest cinnamic acid and potassium cinnamate improve postharvest quality and storability of 'Kyoho' grapes.Frontiers in plant science · 2025Article
- Haplotype-resolved T2T genome assemblies and pangenome graph of pear reveal diverse patterns of allele-specific expression and the genomic basis of fruit quality traits.Plant communications · 2024Article
- Molecular Characteristics of the Malate Dehydrogenase (MDH) Gene Family inInternational journal of molecular sciences · 2024Article
- Overexpression of a Grape WRKY Transcription FactorInternational journal of molecular sciences · 2024Article
- Glucose uptake from the rhizosphere mediated by MdDOF3-MdHT1.2 regulates drought resistance in apple.Plant biotechnology journal · 2024Article
- In-Depth Characterization ofPlants (Basel, Switzerland) · 2024Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The content of organic acids greatly influences the taste and storage life of fleshy fruit. Our current understanding of the molecular mechanism of organic acid accumulation in apple (Malus domestica) fruit focuses on the aluminum-activated malate transporter 9/Ma1 gene. In this study, we identified a candidate gene, MdWRKY126, for controlling fruit acidity independent of Ma1 using homozygous recessive mutants of Ma1, namely Belle de Boskoop "BSKP" and Aifeng "AF." Analyses of transgenic apple calli and flesh and tomato (Solanum lycopersicum) fruit demonstrated that MdWRKY126 was substantially associated with malate content. MdWRKY126 was directly bound to the promoter of the cytoplasmic NAD-dependent malate dehydrogenase MdMDH5 and promoted its expression, thereby enhancing the malate content of apple fruit. In MdWRKY126 overexpressing calli, the mRNA levels of malate-associated transporters and proton pump genes also significantly increased, which contributed to the transport of malate accumulated in the cytoplasm to the vacuole. These findings demonstrated that MdWRKY126 regulates malate anabolism in the cytoplasm and coordinates the transport between cytoplasm and vacuole to regulate malate accumulation. Our study provides useful information to improve our understanding of the complex mechanism regulating apple fruit acidity.
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