Evidence map›Paper›PMID 35078234›Full record

ArticleRheumatology (Oxford, England)2022

Disparities in the prevalence of clinical features between systemic juvenile idiopathic arthritis and adult-onset Still's disease.

Piero Ruscitti, Valentina Natoli, Alessandro Consolaro, Roberta Caorsi, Silvia Rosina, Gabriella Giancane, Roberta Naddei, Ilenia Di Cola, Claudia Di Muzio, Onorina Berardicurti and 23 more

Open access · hybridAbstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  13. Criteria for Cytokine Storm Syndromes.Advances in experimental medicine and biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 11 institutions in 1 country.

Piero RuscittiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.
Valentina NatoliDipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli Studi di Genova, Genoa.
Alessandro ConsolaroDipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli Studi di Genova, Genoa.
Roberta CaorsiUOC Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa.ORCID 0000-0003-0131-7846
Silvia RosinaUOC Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa.
Gabriella GiancaneDipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli Studi di Genova, Genoa.
Roberta NaddeiUOC Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa.
Ilenia Di ColaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.
Claudia Di MuzioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.
Onorina BerardicurtiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.ORCID 0000-0002-2808-1581
Daniela IaconoDepartment of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples.
Ilenia PantanoDepartment of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples.
Gelsomina RozzaDepartment of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples.
Silvia RossiRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia.
Ludovico De StefanoRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia.
Silvia BalduzziRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia.
Antonio VitaleResearch Center of Systemic Auto Inflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Policlinico 'Le Scotte', University of Siena, Siena.
Francesco CasoRheumatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples.ORCID 0000-0002-8928-2520
Luisa CostaRheumatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples.ORCID 0000-0001-7022-9685
Marcella PreteRheumatic and Systemic Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Bari.
Luca NavariniRheumatology and Immunology Unit, Department of Medicine, University of Rome Campus Biomedico, Rome.
Annamaria IagnoccoAcademic Rheumatology Centre, Ospedale Mauriziano - Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Turin.
Fabiola AtzeniRheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina.
Giuliana GugginoRheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital 'P. Giaccone', Palermo.ORCID 0000-0003-2479-6958
Federico PerosaRheumatic and Systemic Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Bari.
Luca CantariniResearch Center of Systemic Auto Inflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Policlinico 'Le Scotte', University of Siena, Siena.ORCID 0000-0002-7352-1275
Bruno FredianiResearch Center of Systemic Auto Inflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Policlinico 'Le Scotte', University of Siena, Siena.
Carlomaurizio MontecuccoRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia.
Francesco CicciaDepartment of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples.ORCID 0000-0002-9352-1264
Paola CiprianiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.
Marco GattornoUOC Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa.ORCID 0000-0003-0704-1916
Roberto GiacomelliRheumatology and Immunology Unit, Department of Medicine, University of Rome Campus Biomedico, Rome.
Angelo RavelliDipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli Studi di Genova, Genoa.
Istituto Giannina Gaslini · ITUniversity of L'Aquila · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Pavia · ITUniversity of Siena · ITUniversità Campus Bio-Medico · ITUniversity of Bari Aldo Moro · ITUniversity of Naples Federico II · ITA. O. Ordine Mauriziano di Torino · ITUniversity of Genoa · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare clinical features and treatments of patients with systemic JIA (sIJA) and adult-onset Still's disease (AOSD).

methodsThe clinical charts of consecutive patients with sJIA by International League of Association of Rheumatology criteria or AOSD by Yamaguchi criteria were reviewed. Patients were seen at a large paediatric rheumatology referral centre or at 10 adult rheumatology academic centres. Data collected included clinical manifestations, inflammation biomarkers, systemic score, macrophage activation syndrome (MAS), parenchymal lung disease, disease course, disability, death and medications administered.

resultsA total of 166 patients (median age at diagnosis 5 years) with sJIA and 194 patients with AOSD (median age at diagnosis 41 years) were included. The frequency of fever, rash, arthralgia, abdominal pain, MAS, parenchymal lung disease and increased acute phase reactants and ferritin were comparable between the two cohorts. Patients with sJIA had a higher prevalence of arthritis, whereas patients with AOSD had experienced leucocytosis and extra-articular organ involvement more frequently. Patients with AOSD were given more commonly low-dose corticosteroids, whereas biologic DMARDs were administered first-line more frequently in patients with sJIA.

conclusionWe found remarkable disparities in the prevalence of clinical manifestations between the two illnesses, which may partly depend on their classification by different criteria.

Indexed as

Antirheumatic AgentsArthritis, JuvenileBiological ProductsLung DiseasesMacrophage Activation SyndromeStill's Disease, Adult-OnsetAcute-Phase ProteinsAdrenal Cortex HormonesAdultBiomarkersChildFerritinsHumansPrevalenceAcute-Phase ProteinsAdrenal Cortex HormonesAntirheumatic AgentsBiological ProductsBiomarkersFerritinsadult-onset Still’s diseasesystemic juvenile idiopathic arthritis

Identifiers

PMID35078234
PMCPMC9536787
OpenAlexW4206985059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.