ArticlePlant physiology2022
γ-Aminobutyric acid plays a key role in plant acclimation to a combination of high light and heat stress.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Heat stress responses of plants during adaptation to high temperature environments: A review of recent advances and insights.Plant signaling & behavior · 2026Review
- Article
- γ-Aminobutyric Acid (GABA) enhances heat tolerance in rice via integrated antioxidant defense, metabolic homeostasis and heat shock response.BMC plant biology · 2026Article
- Rumen-Protected Glucose Supplementation Enhances Yak Calf Growth Through Gut Microbiota-Metabolic Interactions.Animals : an open access journal from MDPI · 2026Article
- Poikilohydria, polyols, and homeoviscosity: lichen metabolomic remodeling across environmental gradients.Frontiers in plant science · 2026Article
- Interaction Between CsATG8f and CsRAP2.12 Modulates Antioxidant Defense and Hypoxia Response During Submergence inInternational journal of molecular sciences · 2025Article
- Transcriptomic Meta-Analysis Reveals Hub Genes Integrating Multiple Abiotic Stress Responses in Wheat.Food science & nutrition · 2025Article
- Can autophagy enhance crop resilience to environmental stress?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Genomic introgression underlies environmental adaptation in three species of Chinese wingnuts,Plant diversity · 2025Article
- Mechanisms of plant acclimation to multiple abiotic stresses.Communications biology · 2025Review
- Review
- Cost-effective production ofBiology methods & protocols · 2025Article
- Characterization of the Calmodulin-Like Protein Family in Chara braunii and their Conserved Interaction with the Calmodulin-Binding Transcription Activator Family.Plant & cell physiology · 2024Article
- GABA does not regulate stomatal CO2 signalling in Arabidopsis.Journal of experimental botany · 2024Article
- Advances in Plant GABA Research: Biological Functions, Synthesis Mechanisms and Regulatory Pathways.Plants (Basel, Switzerland) · 2024Review
- Relationship between the GABA Pathway and Signaling of Other Regulatory Molecules.International journal of molecular sciences · 2024Review
- MdSINA2-MdNAC104 Module Regulates Apple Alkaline Resistance by Affecting γ-Aminobutyric Acid Synthesis and Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Surviving a Double-Edged Sword: Response of Horticultural Crops to Multiple Abiotic Stressors.International journal of molecular sciences · 2024Review
- Exogenous treatment with N-acetylglutamic acid confers tolerance to heat stress in plants.Plant biotechnology (Tokyo, Japan) · 2024Article
- GABA: a key player of abiotic stress regulation.Plant signaling & behavior · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants are frequently subjected to different combinations of abiotic stresses, such as high light (HL) intensity, and elevated temperatures. These environmental conditions pose a threat to agriculture production, affecting photosynthesis, and decreasing yield. Metabolic responses of plants, such as alterations in carbohydrates and amino acid fluxes, play a key role in the successful acclimation of plants to different abiotic stresses, directing resources toward stress responses, and suppressing growth. Here we show that the primary metabolic response of Arabidopsis (Arabidopsis thaliana) plants to HL or heat stress (HS) is different from that of plants subjected to a combination of HL and HS (HL+HS). We further demonstrate that the combined stress results in a unique metabolic response that includes increased accumulation of sugars and amino acids coupled with decreased levels of metabolites participating in the tricarboxylic acid cycle. Among the amino acids exclusively accumulated during HL+HS, we identified the nonproteinogenic amino acid γ-aminobutyric acid (GABA). Analysis of different mutants deficient in GABA biosynthesis (GLUTAMATE DESCARBOXYLASE 3 [gad3]) as well as mutants impaired in autophagy (autophagy-related proteins 5 and 9 [atg5 and atg9]), revealed that GABA plays a key role in the acclimation of plants to HL+HS, potentially by promoting autophagy. Taken together, our findings identify a role for GABA in regulating plant responses to combined stress.
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