ArticleCerebral cortex (New York, N.Y. : 1991)2022
Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Global Alterations of Whole Brain Structural Connectome in Parkinson's Disease: A Meta-analysis.Neuropsychology review · 2023Pooled it
- Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.NeuroImage. Clinical · 2026Article
- Topological disruptions of metabolic brain networks in early-stage chronic kidney disease.BMC medical imaging · 2026Article
- Characteristics and mechanisms of cognitive impairment in Parkinson disease.Nature reviews. Neurology · 2026Review
- Multimodal brain network topology and enhanced computer-aided diagnosis in Parkinson's Disease: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
- Structural covariance network alterations across the spectrum of cognitive status in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Review
- Brain functional mechanisms of acupuncture treatment for early-stage non-tremor Parkinson's disease: a resting-state fMRI study.Frontiers in neurology · 2026Observational
- Impaired event-related theta spectral coherence in emotional facial expression processing in neurodegenerative disorders.Frontiers in human neuroscience · 2026Article
- A Multi-omics Framework Based on Machine Learning as a Predictor of Cognitive Impairment Progression in Early Parkinson's Disease.Neurology and therapy · 2025Article
- A multimodal MRI framework employing machine learning for detecting beginning cognitive impairment in Parkinson's disease.Frontiers in neuroscience · 2025Article
- Brain functional network topology and connectivity in primary blepharospasm.Frontiers in systems neuroscience · 2025Article
- Brain functional network abnormalities in Parkinson's disease patients at different disease stages.Frontiers in neuroscience · 2025Article
- Personalized temporal interference stimulation targeting striatum reduces functional stability and dynamic connectivity variability in the sensorimotor network.Frontiers in neuroscience · 2025Article
- Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson's disease with later cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.Current neurology and neuroscience reports · 2024Review
- A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease.Neural regeneration research · 2024Review
- Magnetic resonance imaging of brain structural and functional changes in cognitive impairment associated with Parkinson's disease.Frontiers in aging neuroscience · 2024Review
- Reorganized brain functional network topology in stable and progressive mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Topological disruption of low- and high-order functional networks in presbycusis.Brain communications · 2024Article
- Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment.Brain and behavior · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Mild cognitive impairment in Parkinson's disease (PD-M) is related to a high risk of dementia. This study explored the whole-brain functional networks in early-stage PD-M. Forty-one patients with PD classified as cognitively normal (PD-N, n = 17) and PD-M (n = 24) and 24 demographically matched healthy controls (HC) underwent clinical and neuropsychological evaluations and resting-state functional magnetic resonance imaging. The global, regional, and modular topological characteristics were assessed in the brain functional networks, and their relationships to cognitive scores were tested. At the global level, PD-M and PD-N exhibited higher characteristic path length and lower clustering coefficient, local and global efficiency relative to HC. At the regional level, PD-M and PD-N showed lower nodal centrality in sensorimotor regions relative to HC. At the modular level, PD-M showed lower intramodular connectivity in default mode and cerebellum modules, and lower intermodular connectivity between default mode and frontoparietal modules than PD-N, correlated with Montreal Cognitive Assessment scores. Early-stage PD patients showed weaker small-worldization of brain networks. Modular connectivity alterations were mainly observed in patients with PD-M. These findings highlight the shared and distinct brain functional network dysfunctions in PD-M and PD-N, and yield insight into the neurobiology of cognitive decline in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.