Evidence map›Paper›PMID 35077917›Full record

ArticleImmunobiology2022

IgD ligation allows peritoneal cavity B cell proliferation.

Jennifer Londregan, Jeffrey Maslanka, Naomi Goldman, John Somerville, James E Riggs

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jennifer LondreganBiology Department, Rider University, Lawrenceville, NJ 08648, USA.
Jeffrey MaslankaBiology Department, Rider University, Lawrenceville, NJ 08648, USA.
Naomi GoldmanBiology Department, Rider University, Lawrenceville, NJ 08648, USA.
John SomervilleBiology Department, Rider University, Lawrenceville, NJ 08648, USA.
James E RiggsBiology Department, Rider University, Lawrenceville, NJ 08648, USA. Electronic address: riggs@rider.edu.
Rider University · US

Funding

EPO Increases Macrophage SuppressionR15CA173688 · NCI · RIDER UNIVERSITY · PI RIGGS, JAMES EDWARD · 2014 to 2014
$365k
Immunoregulation in the Peritoneal CavityR15AI060356 · NIAID · RIDER UNIVERSITY · PI RIGGS, JAMES EDWARD · 2005 to 2005
$243k
Macrophage Density Regulates T CellsR15CA136901 · NCI · RIDER UNIVERSITY · PI RIGGS, JAMES EDWARD · 2009 to 2009
$199k
NCI NIH HHS R15 CA136901NCI NIH HHS R15 CA173688NIAID NIH HHS R15 AI060356
6 · The paper itself

Abstract

Atypical cytokine production and immune cell subset ratios, particularly those that include high proportions of macrophages, characterize tumor microenvironments (TMEs). TMEs can be modeled by culturing peritoneal cavity (PerC) cells which have a high macrophage to lymphocyte ratio. With TCR or BCR ligation, PerC lymphocyte proliferation is tempered by macrophages. However, PHA (T cells) and anti-CD40 (B cells) are activators that induce proliferation. Herein, we report that ligating IgD, in contrast to IgM, triggers PerC B cell proliferation. IL-4 addition enhanced the IgD response for BALB/c PerC B cells but suppressed that of C57BL/6 mice. Intriguingly, concurrent ligation of IgD and CD3

Indexed as

Lymphocyte ActivationPeritoneal CavityAnimalsCell ProliferationImmunoglobulin DMiceMice, Inbred C57BLImmunoglobulin DB cellCD3(ε)IgDMacrophagePeritoneal cavityT cellTumor microenvironment

Identifiers

PMID35077917
PMCPMC8918009
OpenAlexW4205921451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.