Evidence map›Paper›PMID 35077680›Full record

ArticleDevelopmental cell2022

Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.

Rani Ojha, Ishaq Tantray, Suman Rimal, Siddhartha Mitra, Sam Cheshier, Bingwei Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 40 citations in OpenAlex.

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  11. Oxphos targeting ofFrontiers in oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rani OjhaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Ishaq TantrayDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Suman RimalDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Siddhartha MitraStem Cell Institute, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplant, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sam CheshierStem Cell Institute, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurosurgery, Division of Pediatric Neurosurgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
Bingwei LuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: bingwei@stanford.edu.
Stanford University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Utah · US

Funding

Molecular Genetic Analysis of TORC1 and TORC2 Signaling in Neuronal MaintenanceR01NS084412 · NINDS · STANFORD UNIVERSITY · PI Bingwei Lu · 2014 to 2026
$4.9M
Genetic Control of Neural Stem Cell HomeostasisR01NS083417 · NINDS · STANFORD UNIVERSITY · PI LU, BINGWEI · 2013 to 2022
$3.5M
Mitochondrial inner membrane architecture in skeletal muscle pathophysiologyR01AR074875 · NIAMS · STANFORD UNIVERSITY · PI LU, BINGWEI · 2019 to 2023
$2.0M
NIAMS NIH HHS R01 AR074875NINDS NIH HHS R01 NS083417NINDS NIH HHS R01 NS084412
6 · The paper itself

Abstract

Metabolic flexibility is a hallmark of many cancers where mitochondrial respiration is critically involved, but the molecular underpinning of mitochondrial control of cancer metabolic reprogramming is poorly understood. Here, we show that reverse electron transfer (RET) through respiratory chain complex I (RC-I) is particularly active in brain cancer stem cells (CSCs). Although RET generates ROS, NAD

Indexed as

AnimalsCell Line, TumorCell ProliferationCell RespirationDisease Models, AnimalDrosophilaElectronsElectron TransportElectron Transport Complex IGlioblastomaHumansMiceMice, Inbred NODMitochondriaNADNeoplastic Stem CellsElectron Transport Complex INADReactive Oxygen SpeciesReceptors, Notchglioblastoma multiformeinflammationmetabolic reprogrammingmitochondrial complex INAD(+)/NADHnon-canonical Notch signalingreactive oxygen speciesreverse electron transportSirtuinWarburg effect

Identifiers

PMID35077680
PMCPMC8852348
OpenAlexW4206980687

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.