Evidence map›Paper›PMID 35077612›Full record

ArticleChemMedChem2022

Synthesis of Aminoethyl-Substituted Piperidine Derivatives as σ

Catharina Holtschulte, Frederik Börgel, Stefanie Westphälinger, Dirk Schepmann, Gianluca Civenni, Erik Laurini, Domenico Marson, Carlo V Catapano, Sabrina Pricl, Bernhard Wünsch

Abstract read
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. [Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  5. Experimental study of local anesthetic and antiarrhythmic activities of fluorinated ethynylpiperidine derivatives.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Catharina HoltschulteInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149, Münster, Germany.
Frederik BörgelInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149, Münster, Germany.
Stefanie WestphälingerInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149, Münster, Germany.
Dirk SchepmannInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149, Münster, Germany.
Gianluca CivenniInstitute of Oncology Research, Università della Svizzera Italiana (USI), Via Vincenzo Vela 6, 6500, Bellinzona, Switzerland.
Erik LauriniMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, 34127, Trieste, Italy.
Domenico MarsonMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, 34127, Trieste, Italy.
Carlo V CatapanoInstitute of Oncology Research, Università della Svizzera Italiana (USI), Via Vincenzo Vela 6, 6500, Bellinzona, Switzerland.
Sabrina PriclMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, 34127, Trieste, Italy.
Bernhard WünschInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149, Münster, Germany.ORCID 0000-0002-9030-8417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel σ

Indexed as

Antineoplastic AgentsPiperidinesReceptors, sigmaCarcinoma, Non-Small-Cell LungCell Line, TumorHumansLigandsLung NeoplasmsMaleProstatic NeoplasmsStructure-Activity RelationshipAntineoplastic AgentsLigandspiperidinePiperidinesReceptors, sigmaandrogen negative human prostate cancer cells DU145.antitumor activitycytotoxic activityhuman non-small cell lung cancer cells A427lipophilic ligand efficiencylogD7.4 valuesmolecular dynamics simulationspiperidinesselectivity over σ2 receptorsstructure affinity relationshipssynthesisσ1 affinityσ1 receptor ligands

Identifiers

PMID35077612
PMCPMC9303367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.