Evidence map›Paper›PMID 35077501›Full record

ArticlePloS one2022

Association of HIV status and treatment characteristics with VIA screening outcomes in Malawi: A retrospective analysis.

Samuel Lewis, Misheck Mphande, Florence Chibwana, Temwa Gumbo, Ben Allan Banda, Hitler Sigauke, Agnes Moses, Sundeep Gupta, Risa M Hoffman, Corrina Moucheraud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Samuel LewisUniversity of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, United States of America.ORCID 0000-0001-5649-6584
Misheck MphandePartners in Hope Medical Center, Lilongwe, Malawi.
Florence ChibwanaPartners in Hope Medical Center, Lilongwe, Malawi.
Temwa GumboPartners in Hope Medical Center, Lilongwe, Malawi.
Ben Allan BandaPartners in Hope Medical Center, Lilongwe, Malawi.
Hitler SigaukePartners in Hope Medical Center, Lilongwe, Malawi.
Agnes MosesPartners in Hope Medical Center, Lilongwe, Malawi.
Sundeep GuptaUniversity of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, United States of America.
Risa M HoffmanUniversity of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, United States of America.
Corrina MoucheraudDepartment of Health Policy and Management, University of California Los Angeles Fielding School of Public Health, Los Angeles, CA, United States of America.
University of California, Los Angeles · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
NCATS NIH HHS KL2 TR001882NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

backgroundAlthough evidence from high-resource settings indicates that women with HIV are at higher risk of acquiring high-risk HPV and developing cervical cancer, data from cervical cancer "screen and treat" programs using visual inspection with acetic acid (VIA) in lower-income countries have found mixed evidence about the association between HIV status and screening outcomes. Moreover, there is limited evidence regarding the effect of HIV-related characteristics (e.g., viral suppression, treatment factors) on screening outcomes in these high HIV burden settings.

methodsThis study aimed to evaluate the relationship between HIV status, HIV treatment, and viral suppression with cervical cancer screening outcomes. Data from a "screen and treat" program based at a large, free antiretroviral therapy (ART) clinic in Lilongwe, Malawi was retrospectively analyzed to determine rates of abnormal VIA results and suspected cancer, and coverage of same-day treatment. Multivariate logistic regression assessed associations between screening outcomes and HIV status, and among women living with HIV, viremia, ART treatment duration and BMI.

resultsOf 1405 women receiving first-time VIA screening between 2017-2019, 13 (0.9%) had suspected cancer and 68 (4.8%) had pre-cancerous lesions, of whom 50 (73.5%) received same-day lesion treatment. There was no significant association found between HIV status and screening outcomes. Among HIV+ women, abnormal VIA was positively associated with viral load ≥ 1000 copies/mL (aOR 3.02, 95% CI: 1.22, 7.49) and negatively associated with ART treatment duration (aOR 0.88 per additional year, 95% CI: 0.80, 0.98).

conclusionIn this population of women living with HIV with high rates of ART coverage and viral suppression, HIV status was not significantly associated with abnormal cervical cancer screening results. We hypothesize that ART treatment and viral suppression may mitigate the elevated risk of cervical cancer for women living with HIV, and we encourage further study on this relationship in high HIV burden settings.

Indexed as

HIV-1HIV InfectionsPapillomavirus InfectionsUterine Cervical NeoplasmsAdultAnti-Retroviral AgentsFemaleHumansMalawiMiddle AgedAnti-Retroviral Agents

Identifiers

PMID35077501
PMCPMC8789172
OpenAlexW4206922439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.