ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2022
Cancer Risks Associated With
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05681416 (Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer), which is not on this map. Cited by 183 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 6 pooled it
45.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer
Who cites it
183 citing papers in PubMed, 6 syntheses or guidelines pooled it, 262 citations in OpenAlex.
- Causal inference in the diagnosis and prognosis of ovarian cancer: current state and future directions.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Pooled it
- [Hereditary genetic testing and its application in the diagnosis, treatment, and prevention of breast cancer].Magyar onkologia · 2025Guideline
- Pathogenic variants inJournal of medicine and life · 2025Pooled it
- Pooled it
- Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.Breast cancer research : BCR · 2023Pooled it
- Risk of developing a second primary cancer in male breast cancer survivors: a systematic review and meta-analysis.British journal of cancer · 2022Pooled it
- Prevalence of Helicobacter pylori Exposure and Risk Factors Among BRCA1 and BRCA2 Carriers.International journal of cancer · 2026Article
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- Germline whole-exome sequencing identifies CTNND1 as a candidate gene for hereditary gastric cancer in a large Brazilian cohort.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.Cancer discovery · 2026Article
- Impact of BRCA1/2 status on young women's sexual function, relationships, and reproduction after predictive genetic testing.European journal of human genetics : EJHG · 2026Article
- Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer.Human genetics · 2026Article
- Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations.Communications medicine · 2026Review
- Identification and Computational Analysis ofMedical sciences (Basel, Switzerland) · 2026Article
- Optimized SPE-HPLC-FLD Method for the Simultaneous Determination of Olaparib, Propranolol, and Furosemide in Human Urine.Biomedical chromatography : BMC · 2026Article
- Locally advanced breast cancer in an elderly male with end-stage renal disease: A case report.Oncology letters · 2026Article
- Next-generation sequencing-based characterization of BRCA1/2 variants across multiple tumor types in Vietnamese patients.BMC cancer · 2026Article
- Sequence-Anchored Shared Tumor-Specific Epitopes for Pre-Manufactured HLA-Matched mRNA Cancer Vaccine Libraries: A Pan-Cancer Framework.Biomolecules · 2026Article
- Aging and cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
123 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byDo Female2022
Authors and funding
102 authors at 20 institutions in 20 countries.
Shuai LiCenter for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-8696-8594
Valentina SilvestriDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-0712-9379
Goska LeslieCenter for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-5756-6222
Timothy R RebbeckHarvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0002-4799-1900
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA.ORCID 0000-0001-5053-0390
John L HopperCenter for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-8567-173X
Henriette Roed NielsenDepartment of Clinical Genetics, Odense University Hospital, Odence, Denmark.
Andrew LeeCenter for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0677-0252
Xin YangCenter for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0037-3790
Lesley McGuffogCenter for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Michael T ParsonsDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-3242-8477
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.ORCID 0000-0002-4226-6435
Norbert ArnoldDepartment of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
Muriel BelottiService de Génétique, Institut Curie, Paris, France.
Åke BorgDivision of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0002-5793-132X
Bruno BuecherService de Génétique, Institut Curie, Paris, France.
Saundra S BuysDepartment of Medicine and Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT.ORCID 0000-0003-4120-5697
Sandrine M CaputoService de Génétique, Institut Curie, Paris, France.ORCID 0000-0001-5338-9388
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, NY.ORCID 0000-0003-3438-5685
Chrystelle ColasService de Génétique, Institut Curie, Paris, France.
Sarah V ColonnaDepartment of Medicine and Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT.
Jackie CookSheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA.
Miguel de la HoyaMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clinico San Carlos), Madrid, Spain.ORCID 0000-0002-8113-1410
Antoine de PauwService de Génétique, Institut Curie, Paris, France.ORCID 0000-0003-3898-073X
Hélène DelhomelleService de Génétique, Institut Curie, Paris, France.
Jacqueline EasonNottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-7247-282X
D Gareth EvansDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Center, Manchester, United Kingdom.
Ulrike FaustInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Tanja N FehmDepartment of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Florentia FostiraMolecular Diagnostics Laboratory, INRASTES, National Center for Scientific Research "Demokritos", Athens, Greece.ORCID 0000-0003-2751-2332
George FountzilasAristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.ORCID 0000-0001-8045-2186
Megan FroneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.ORCID 0000-0001-8273-8866
Vanesa Garcia-BarberanMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clinico San Carlos), Madrid, Spain.
Pilar GarreMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clinico San Carlos), Madrid, Spain.ORCID 0000-0001-8285-4138
Marion Gauthier-VillarsService de Génétique, Institut Curie, Paris, France.
Andrea GehrigDepartment of Human Genetics, University Würzburg, Würzburg, Germany.
Gord GlendonFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.ORCID 0000-0001-8630-6673
David E GoldgarDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT.ORCID 0000-0003-0697-9347
Lisa GolmardService de Génétique, Institut Curie, Paris, France.ORCID 0000-0002-5158-8284
Mark H GreeneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Eric HahnenCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-1152-8367
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Helen HansonSouthwest Thames Regional Genetics Service, St George's Hospital, London, United Kingdom.ORCID 0000-0002-3303-8713
Tiara HassanBreast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.ORCID 0000-0001-8282-0034
Julia HentschelInstitute of Human Genetics, University Hospital Leipzig, Leipzig, Germany.
Judit HorvathInstitute of Human Genetics, University of Münster, Münster, Germany.
Louise IzattClinical Genetics Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Ramunas JanaviciusFaculty of Medicine, Department of Human and Medical Genetics, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania.
Yue JiaoGenetic Epidemiology of Cancer Team, Inserm U900, Paris, France.ORCID 0000-0001-9872-6034
Esther M JohnDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0003-3259-8003
Beth Y KarlanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.ORCID 0000-0002-9451-2933
Sung-Won KimDepartment of Surgery, Daerim Saint Mary's Hospital, Seoul, South Korea.
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES, National Center for Scientific Research "Demokritos", Athens, Greece.ORCID 0000-0002-0470-0309
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Hong Kong.
Anthony LaugéService de Génétique, Institut Curie, Paris, France.
Jong Won LeeDepartment of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.ORCID 0000-0001-7875-1603
Fabienne LesueurGenetic Epidemiology of Cancer Team, Inserm U900, Paris, France.ORCID 0000-0001-7404-4549
Noura MebiroukGenetic Epidemiology of Cancer Team, Inserm U900, Paris, France.
Alfons MeindlDepartment of Gynecology and Obstetrics, University of Munich, Campus Großhadern, Munich, Germany.
Emmanuelle Mouret-FourmeService de Génétique, Institut Curie, Paris, France.
Hannah MusgraveYorkshire Regional Genetics Service, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
Joanne Ngeow Yuen YieCancer Genetics Service, National Cancer Center, Singapore, Singapore.ORCID 0000-0003-1558-3627
Dieter NiederacherDepartment of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-6231-9226
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Inge Sokilde PedersenMolecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0002-9902-8040
Juliane RamserDivision of Gynaecology and Obstetrics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
Susan J RamusFaculty of Medicine, School of Women's and Children's Health, University of NSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-0005-7798
Johanna RantalaClinical Genetics, Karolinska Institutet, Stockholm, Sweden.
Muhammad U RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-7684-3122
Florian ReichlDepartment of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Julia RitterInstitute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Andreas RumpFaculty of Medicine Carl Gustav Carus, Institute for Clinical Genetics, TU Dresden, Dresden, Germany.ORCID 0000-0001-7116-6364
Marta SantamariñaCentro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Claire SauleService de Génétique, Institut Curie, Paris, France.ORCID 0000-0002-9639-8986
Gunnar SchmidtInstitute of Human Genetics, Hannover Medical School, Hannover, Germany.
Rita K SchmutzlerCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Leigha SenterClinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH.ORCID 0000-0001-9270-8847
Saba ShariffWest Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, United Kingdom.ORCID 0000-0002-9564-4890
Christian F SingerDepartment of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-1294-0027
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-6313-9005
Dominique Stoppa-LyonnetService de Génétique, Institut Curie, Paris, France.ORCID 0000-0002-5438-8309
Christian SutterInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Yen TanDepartment of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Soo Hwang TeoBreast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.ORCID 0000-0002-0444-590X
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.ORCID 0000-0002-4106-5033
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odence, Denmark.
Marc TischkowitzProgram in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.ORCID 0000-0002-7880-0628
Amanda E TolandDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH.ORCID 0000-0002-0271-1792
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ana VegaCentro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.ORCID 0000-0002-7416-5137
Sebastian A WagnerDepartment of Medicine, Hematology/Oncology, Goethe-University Frankfurt, Frankfurt, Germany.ORCID 0000-0002-8629-6310
Shan Wang-GohrkeDepartment of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
Barbara WappenschmidtCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Bernhard H F WeberInstitute of Human Genetics, University Regensburg, Regensburg, Germany.ORCID 0000-0002-8808-7723
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Center for Scientific Research "Demokritos", Athens, Greece.ORCID 0000-0001-7509-3510
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-1337-7897
Douglas F EastonCenter for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-2444-3247
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-1878-2587
Laura OttiniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-8030-0449
Antonis C AntoniouCenter for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9223-3116
Institut Curie · FRUniversity of Cambridge · GBComprehensive Cancer Center Vienna · ATGerman Cancer Research Center · DEInserm · FRInstituto de Investigación Sanitaria del Hospital Clínico San Carlos · ESNational Centre of Scientific Research "Demokritos" · GRQIMR Berghofer Medical Research Institute · AUThe University of Melbourne · AUUniversity of Cologne · DEUniversity of Utah · USCentre for Biomedical Network Research on Rare Diseases · ESColumbia University · USDüsseldorf University Hospital · DEMount Sinai Hospital · CANational Cancer Institute · USOdense University Hospital · DKSapienza University of Rome · ITTUM Klinikum · DEAalborg University Hospital · DK
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MBreast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7MPrecision Assessment and Delivery of Cancer Risks in BRCA 1/2 Mutation CancersR01CA207365 · NCI · DANA-FARBER CANCER INST · PI CHEN, JINBO, REBBECK, TIMOTHY R · 2017 to 2021
$3.6MStudy of Genetic Mutation Carriage in Chinese Populations with Breast CancerR03CA130065 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI WEST, DEE WAYNE · 2007 to 2008
$126kCancer Research UK 20861Cancer Research UK 23382Cancer Research UK 26886NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS N02 CP011019NCI NIH HHS N02 CP065504NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA207365NCI NIH HHS R03 CA130065NCI NIH HHS UM1 CA164920Wellcome Trust 203477/Z/16/Z
Abstract
purposeTo provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in
methodsWe used data from 3,184
results
conclusionIn addition to female breast and ovarian cancers,
Indexed as
Breast NeoplasmsBreast Neoplasms, MaleOvarian NeoplasmsPancreatic NeoplasmsBRCA1 ProteinBRCA2 ProteinFemaleGenetic Predisposition to DiseaseHeterozygoteHumansInfant, NewbornMaleMutationRiskBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05681416ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.