Evidence map›Paper›PMID 35077199›Full record

ArticleScience signaling2022

Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity in

Germán E Piñas, Michael D DeSantis, C Keith Cassidy, John S Parkinson

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Microorganisms · 2025
    Review
  6. Article
  7. The structural logic of dynamic signaling in the Escherichia coli serine chemoreceptor.Protein science : a publication of the Protein Society · 2024
    Article
  8. Article
  9. Article
  10. The Structural Logic of Dynamic Signaling in thebioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Recent structural advances in bacterial chemotaxis signalling.Current opinion in structural biology · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Germán E PiñasSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-4509-965X
Michael D DeSantisSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-8178-0464
C Keith CassidyDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.ORCID 0000-0001-8106-1187
John S ParkinsonSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-8788-7844
University of Utah · USUniversity of Oxford · GB

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
Intracellular Signaling by Bacterial ChemoreceptorsR01GM019559 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JOHN S PARKINSON · 1985 to 2026
$12.3M
INTRACELLULAR SIGNALING BY BACTERIAL CHEMORECEPTORSR37GM019559 · NIGMS · UNIVERSITY OF UTAH · PI PARKINSON, JOHN S · 1992 to 2001
$806k
Biotechnology and Biological Sciences Research Council BB/S003339/1NCI NIH HHS P30 CA042014NIGMS NIH HHS R01 GM019559NIGMS NIH HHS R37 GM019559
6 · The paper itself

Abstract

The

Indexed as

Escherichia coliEscherichia coli ProteinsChemotaxisHistidine KinaseMethyl-Accepting Chemotaxis ProteinscheA protein, E coliCheW protein, E coliEscherichia coli ProteinsHistidine KinaseMethyl-Accepting Chemotaxis Proteins

Identifiers

PMID35077199
PMCPMC9261748
OpenAlexW4206999464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.