ArticleChemical research in toxicology2022
Formation of Redox-Active Duroquinone from Vaping of Vitamin E Acetate Contributes to Oxidative Lung Injury.
Article in Chemical research in toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Vitamin E acetate and its aerosol activate aryl hydrocarbon receptor signaling and exacerbate inflammation in human U937-derived macrophages.Toxicology in vitro : an international journal published in association with BIBRA · 2026Article
- Differential Regulatory Effects of Cannabinoids and Vitamin E Analogs on Cellular Lipid Homeostasis and Inflammation in Human Macrophages.Antioxidants (Basel, Switzerland) · 2026Article
- Cannabinoid Vaping Products: Regulation, Composition, Toxicological Effects, and Emerging Research.Chemical research in toxicology · 2025Review
- Valorization of Lignin and Its Derived Molecules by Electrocatalytic Oxidation.ACS sustainable chemistry & engineering · 2025Review
- Cannabis concentrate vaping chemistry.Frontiers in toxicology · 2025Review
- Applications of an Electrochemical Sensory Array Coupled with Chemometric Modeling for Electronic Cigarettes.Sensors (Basel, Switzerland) · 2024Article
- Conditions Leading to Ketene Formation in Vaping Devices and Implications for Public Health.Chemical research in toxicology · 2024Article
- Ozonolysis of Terpene Flavor Additives in Vaping Emissions: Elevated Production of Reactive Oxygen Species and Oxidative Stress.Chemical research in toxicology · 2024Article
- Correlation gas chromatography and two-dimensional volatility basis methods to predict gas-particle partitioning for e-cigarette aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2024Article
- Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring.Journal of environmental exposure assessment · 2024Article
- Article
- Review
- Vaping Induced Cannabidiol (CBD) Oxidation Product CBD Quinone Forms Protein Adducts with KEAP1 and Activates KEAP1-Nrf2 Genes.Chemical research in toxicology · 2023Article
- External Factors Modulating Vaping-Induced Thermal Degradation of Vitamin E Acetate.Chemical research in toxicology · 2023Article
- In-situ TD-GCMS measurements of oxidative products of monoterpenes at typical vaping temperatures: implications for inhalation exposure to vaping products.Scientific reports · 2022Article
- Temperature dependence of emission product distribution from vaping of vitamin E acetate.PloS one · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In late 2019, the outbreak of e-cigarette or vaping-associated lung injuries (EVALIs) in the United States demonstrated to the public the potential health risks of vaping. While studies since the outbreak have identified vitamin E acetate (VEA), a diluent of tetrahydrocannabinol (THC) in vape cartridges, as a potential contributor to lung injuries, the molecular mechanisms through which VEA may cause damage are still unclear. Recent studies have found that the thermal degradation of e-liquids during vaping can result in the formation of products that are more toxic than the parent compounds. In this study, we assessed the role of duroquinone (DQ) in VEA vaping emissions that may act as a mechanism through which VEA vaping causes lung damage. VEA vaping emissions were collected and analyzed for their potential to generate reactive oxygen species (ROS) and induce oxidative stress-associated gene expression in human bronchial epithelial cells (BEAS-2B). Significant ROS generation by VEA vaping emissions was observed in both acellular and cellular systems. Furthermore, exposure to vaping emissions resulted in significant upregulation of
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Registered trials
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