Evidence map›Paper›PMID 35076993›Full record

ArticleHuman brain mapping2022

Neural oscillations track recovery of consciousness in acute traumatic brain injury patients.

Joel Frohlich, Julia S Crone, Micah A Johnson, Evan S Lutkenhoff, Norman M Spivak, John Dell'Italia, Joerg F Hipp, Vikesh Shrestha, Jesús E Ruiz Tejeda, Courtney Real and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06321146 (Evaluation of EEG Power Spectrum in Patients With Traumatic Coma), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06321146 unknown statusnot on this mapstarted 2024, after this paper: background citation

Evaluation of EEG Power Spectrum in Patients With Traumatic Coma

TypeobservationalSponsorRenJi HospitalRan2024 to 2026Enrolled210ConditionsComa, Brain Injuries, Traumatic
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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  8. Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Joel FrohlichDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-8382-4344
Julia S CroneDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.
Micah A JohnsonDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.
Evan S LutkenhoffDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.
Norman M SpivakDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-2386-2987
John Dell'ItaliaDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.
Joerg F HippRoche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Vikesh ShresthaDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Jesús E Ruiz TejedaDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Courtney RealDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Paul M VespaDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Martin M MontiDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USRoche (Switzerland) · CHUniversity of Vienna · AT

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
The effects of glycemic control on post-traumatic brain metabolismP01NS058489 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VESPA, PAUL M · 2009 to 2013
$6.2M
MRS Detects Metabolic Dysfunction after Brain InjuryR01NS049471 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VESPA, PAUL M · 2006 to 2009
$1.3M
NINDS NIH HHS NS049471NINDS NIH HHS NS058489NINDS NIH HHS NS100064NINDS NIH HHS P01 NS058489NINDS NIH HHS R01 NS049471NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Electroencephalography (EEG), easily deployed at the bedside, is an attractive modality for deriving quantitative biomarkers of prognosis and differential diagnosis in severe brain injury and disorders of consciousness (DOC). Prior work by Schiff has identified four dynamic regimes of progressive recovery of consciousness defined by the presence or absence of thalamically-driven EEG oscillations. These four predefined categories (ABCD model) relate, on a theoretical level, to thalamocortical integrity and, on an empirical level, to behavioral outcome in patients with cardiac arrest coma etiologies. However, whether this theory-based stratification of patients might be useful as a diagnostic biomarker in DOC and measurably linked to thalamocortical dysfunction remains unknown. In this work, we relate the reemergence of thalamically-driven EEG oscillations to behavioral recovery from traumatic brain injury (TBI) in a cohort of N = 38 acute patients with moderate-to-severe TBI and an average of 1 week of EEG recorded per patient. We analyzed an average of 3.4 hr of EEG per patient, sampled to coincide with 30-min periods of maximal behavioral arousal. Our work tests and supports the ABCD model, showing that it outperforms a data-driven clustering approach and may perform equally well compared to a more parsimonious categorization. Additionally, in a subset of patients (N = 11), we correlated EEG findings with functional magnetic resonance imaging (fMRI) connectivity between nodes in the mesocircuit-which has been theoretically implicated by Schiff in DOC-and report a trend-level relationship that warrants further investigation in larger studies.

Indexed as

Brain InjuriesBrain Injuries, TraumaticConsciousnessConsciousness DisordersElectroencephalographyHumansbiomarkercomaconsciousnessEEGmesocircuitneural oscillationstraumatic brain injury

Identifiers

PMID35076993
PMCPMC8933330
OpenAlexW4210434047

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.