ArticleInternational journal of cancer2022
Differential Orthopedia Homeobox expression in pulmonary carcinoids is associated with changes in DNA methylation.
Article in International journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- IASLC Update on Classification of Pulmonary Neuroendocrine Neoplasms.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome.Endocrine pathology · 2025Article
- Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets.Journal of translational medicine · 2025Article
- Absence of orthopaedia homeobox protein (OTP) expression is associated with disease spread and adverse outcome in pulmonary carcinoid tumour patients.Virchows Archiv : an international journal of pathology · 2025Article
- Chromothripsis-Mediated Small Cell Lung Carcinoma.Cancer discovery · 2025Article
- Article
- Multi-tissue DNA methylation aging clocks for sea lions, walruses and seals.Communications biology · 2023Article
- Orthopedia homeobox protein (OTP) in the diagnostic and prognostic workup of pulmonary carcinoid tumors.Translational lung cancer research · 2023Article
- Differential Orthopedia Homeobox expression in pulmonary carcinoids is associated with changes in DNA methylation.International journal of cancer · 2022Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Limited number of tumor types have been examined for Orthopedia Homeobox (OTP) expression. In pulmonary carcinoids, loss of expression is a strong indicator of poor prognosis. Here, we investigated OTP expression in 37 different tumor types, and the association between OTP expression and DNA methylation levels in lung neuroendocrine neoplasms. We analyzed publicly available multi-omics data (whole-exome-, whole-genome-, RNA sequencing and Epic 850K-methylation array) of 58 typical carcinoids, 27 atypical carcinoids, 69 large cell neuroendocrine carcinoma and 51 small cell lung cancer patients and TCGA (The Cancer Genome Atlas) data of 33 tumor types. 850K-methylation analysis was cross-validated using targeted pyrosequencing on 35 carcinoids. We report bimodality of OTP expression in carcinoids (OTP
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