Evidence map›Paper›PMID 35076852›Full record

ArticleMolecular biology reports2022

Association of insulin-like growth factor binding protein-7 promoter methylation with esophageal cancer in peripheral blood.

Zehra Kaya, Necat Almalı, Elif Sena Sahin, Seren Duran, Gökhan Görgisen, Can Ates

Abstract read
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In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zehra KayaDepartment of Medical Biology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey. zkaya@yyu.edu.tr.ORCID http://orcid.org/0000-0001-6222-7882
Necat AlmalıDepartment of General Surgery, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey.
Elif Sena SahinDepartment of Medical Biology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey.
Seren DuranDepartment of Medical Biology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey.
Gökhan GörgisenDepartment of Medical Genetics, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey.
Can AtesDepartment of Biostatistics, Faculty of Medicine, Aksaray University, Aksaray, Turkey.
Van Yüzüncü Yıl Üniversitesi · TRAksaray University · TR

Funding

Yüzüncü Yil Üniversitesi TSA-2018-6583
6 · The paper itself

Abstract

backgroundThe insulin-like growth factor (IGF) signaling pathway has an important role in many cancers, including esophageal cancer (EC). IGF-binding protein 7 (IGFBP7) is one of the proteins in this signaling pathway, and its role in cancer has not yet been fully clarified. In the present study, we evaluated the clinical relevance of IGFBP7 methylation status and mRNA expression in EC patients compared to healthy controls. We also investigated whether IGFBP7 methylation status affects mRNA expression.

methodsThe study comprised 100 EC patients and 105 healthy controls. Methylation specific PCR (MSP) was used to examine IGFBP7's promoter methylation and real-time quantitative reverse transcription PCR (qRT-PCR) was used to assess IGFBP7 mRNA expression.

resultsThe IGFBP7 promoter methylation was significantly higher in controls than in EC patients (p < 0.05). IGFBP7 mRNA expression was significantly lower in EC patients compared to controls, especially in those over 55 years old (p < 0.0001). The globulin level and reflux were significantly higher in IGFBP7-unmethylated patients compared to IGFBP7 methylated patients (p = 0.01). In EC patients, however, there was no significant relationship between IGFBP7 mRNA expression and methylation in the peripheral blood (p = 0.33). In addition, neither IGFBP7 mRNA expression nor methylation were shown to be linked with survival (p > 0.05).

conclusionOur study indicated that promoter unmethylation and mRNA expression of the IGFBP7 promoter in peripheral blood could be different biomarkers for EC. Furthermore, unmethylation of the IGFBP7 promoter in EC patients was associated with reflux and elevated globulin levels. More studies with a larger number of cases is needed to confirm this association.

Indexed as

DNA MethylationEsophageal NeoplasmsInsulin-Like Growth Factor Binding ProteinsGlobulinsHumansMiddle AgedPromoter Regions, GeneticRNA, MessengerGlobulinsinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsRNA, MessengerEsophageal cancerIGFBP7MethylationmRNA expression

Identifiers

PMID35076852
OpenAlexW4210297742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.