Evidence map›Paper›PMID 35076825›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022

Clinical utility of PTSD, resilience, sleep, and blast as risk factors to predict poor neurobehavioral functioning following traumatic brain injury: A longitudinal study in U.S. military service members.

Rael T Lange, Louis M French, Jason M Bailie, Victoria C Merritt, Cassandra L Pattinson, Lars D Hungerford, Sara M Lippa, Tracey A Brickell

Abstract read
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In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Rael T LangeTraumatic Brain Injury Center of Excellence, Silver Spring, MD, USA. rael.lange@gmail.com.
Louis M FrenchTraumatic Brain Injury Center of Excellence, Silver Spring, MD, USA.
Jason M BailieTraumatic Brain Injury Center of Excellence, Silver Spring, MD, USA.
Victoria C MerrittVA San Diego Healthcare System, San Diego, CA, USA.
Cassandra L PattinsonUniversity of Queensland, Brisbane, QLD, Australia.
Lars D HungerfordTraumatic Brain Injury Center of Excellence, Silver Spring, MD, USA.
Sara M LippaWalter Reed National Military Medical Center, Bethesda, MD, USA.
Tracey A BrickellTraumatic Brain Injury Center of Excellence, Silver Spring, MD, USA.
General Dynamics (United States) · USWalter Reed National Military Medical Center · USThe University of Queensland · AUUniformed Services University of the Health Sciences · USUniversity of British Columbia · CAVA San Diego Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study examined the clinical utility of post-traumatic stress disorder (PTSD), low resilience, poor sleep, and lifetime blast exposure as risk factors for predicting future neurobehavioral outcome following traumatic brain injury (TBI).

methodsParticipants were 591 U.S. military service members and veterans who had sustained a TBI (n = 419) or orthopedic injury without TBI (n = 172). Participants completed the Neurobehavioral Symptom Inventory, PTSD Checklist, and the TBI-Quality of Life (TBI-QOL) scale at baseline and follow-up.

resultsUsing the four risk factors at baseline, 15 risk factor combinations were examined by calculating odds ratios to predict poor neurobehavioral outcome at follow-up (i.e., number of abnormal scores across five TBI-QOL scales [e.g., Fatigue, Depression]). The vast majority of risk factor combinations resulted in odds ratios that were considered to be clinically meaningful (i.e., ≥ 2.5) for predicting poor outcome. The risk factor combinations with the highest odds ratios included PTSD singularly, or in combination with poor sleep and/or low resilience (odds ratios = 4.3-72.4). However, poor sleep and low resilience were also strong predictors in the absence of PTSD (odds ratios = 3.1-29.8).

conclusionPTSD, poor sleep, and low resilience, singularly or in combination, may be valuable risk factors that can be used clinically for targeted early interventions.

Indexed as

Brain Injuries, TraumaticMilitary PersonnelSleep Initiation and Maintenance DisordersStress Disorders, Post-TraumaticVeteransHumansLongitudinal StudiesQuality of LifeRisk FactorsSleepMilitaryPosttraumatic stressResilienceSleep disturbanceTraumatic brain injury

Identifiers

PMID35076825
OpenAlexW4207051523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.