Penalized-Likelihood PET Image Reconstruction Using Similarity-Driven Median Regularization.

In this paper, we present a new regularized image reconstruction method for positron emission tomography (PET), where an adaptive weighted median regularizer is used in the context of a penalized-likelihood framework. The motivation of our work is to overcome the limitation of the conventional median regularizer, which has proven useful for tomographic reconstruction but suffers from the negative effect of removing fine details in the underlying image when the edges occupy less than half of the window elements. The crux of our method is inspired by the well-known non-local means denoising approach, which exploits the measure of similarity between the image patches for weighted smoothing. However, our method is different from the non-local means denoising approach in that the similarity measure between the patches is used for the median weights rather than for the smoothing weights. As the median weights, in this case, are spatially variant, they provide adaptive median regularization achieving high-quality reconstructions. The experimental results indicate that our similarity-driven median regularization method not only improves the reconstruction accuracy, but also has great potential for super-resolution reconstruction for PET.