Evidence map›Paper›PMID 35076513›Full record

ArticleJournal of functional biomaterials2022

Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study.

Alexandra N Romanova, Alexander A Pugovkin, Maxim V Denisov, Ivan A Ephimov, Dmitry V Gusev, Marian Walter, Thomas Groth, Olga L Bockeria, Tatyana G Le, Anna S Satyukova and 2 more

Abstract read
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In one paragraph

Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra N RomanovaInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.
Alexander A PugovkinInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.ORCID 0000-0003-3915-3971
Maxim V DenisovInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.
Ivan A EphimovInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.
Dmitry V GusevInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.
Marian WalterMedical Information Technology, Helmholtz Institute of Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-4137-5370
Thomas GrothCenter for Digital Biodesign and Personalized Healthcare, I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0000-0001-6647-9657
Olga L BockeriaBakulev Scientific Center for Cardiovascular Surgery, 121552 Moscow, Russia.
Tatyana G LeBakulev Scientific Center for Cardiovascular Surgery, 121552 Moscow, Russia.
Anna S SatyukovaBakulev Scientific Center for Cardiovascular Surgery, 121552 Moscow, Russia.
Sergey V SelishchevInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.
Dmitry V TelyshevInstitute of Biomedical Systems, National Research University of Electronic Technology, 124498 Zelenograd, Moscow, Russia.ORCID 0000-0002-4221-9882

Funding

Deutsche Forschungsgemeinschaft GR1290/13-1Russian Science Foundation 20-49-00404
6 · The paper itself

Abstract

backgroundCurrently, left ventricular assist devices (LVADs) are a successful surgical treatment for patients with end-stage heart failure on the waiting list or with contraindicated heart transplantation. In Russia, Sputnik 1 LVAD was also successfully introduced into clinical practice as a bridge-to-transplant and a destination therapy device. Development of Sputnik 2 LVAD was aimed at miniaturization to reduce invasiveness, optimize hemocompatibility, and improve versatility for patients of various sizes.

methodsWe compared hemolysis level in flow path of the Sputnik LVADs and investigated design aspects influencing other types of blood damage, using predictions of computational fluid dynamics (CFD) and experimental assessment. The investigated operating point was a flow rate of 5 L/min and a pressure head of 100 mm Hg at an impeller rotational speed of 9100 min

resultsMean hemolysis indices predicted with CFD were 0.0090% in the Sputnik 1 and 0.0023% in the Sputnik 2. Averaged values of normalized index of hemolysis obtained experimentally for the Sputnik 1 and the Sputnik 2 were 0.011 ± 0.003 g/100 L and 0.004 ± 0.002 g/100 L, respectively.

conclusionsObtained results indicate obvious improvements in hemocompatibility and sufficiently satisfy the determined miniaturization aim for the Sputnik 2 LVAD development.

Indexed as

computational fluid dynamicshemolysisleft ventricular assist devicemechanical circulatory supportshear stress

Identifiers

PMID35076513
PMCPMC8788462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.