Evidence map›Paper›PMID 35076394›Full record

ArticleeLife2022

Intrinsic mechanisms in the gating of resurgent Na

Joseph L Ransdell, Jonathan D Moreno, Druv Bhagavan, Jonathan R Silva, Jeanne M Nerbonne

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Reinterpretation of the Relationship between Persistent and Resurgent Sodium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joseph L Ransdell *Departments of Medicine, Cardiovascular Division, Washington University, St. Louis, United States.ORCID 0000-0001-5908-9044
Jonathan D Moreno *Developmental Biomedical Engineering, Washington University, St. Louis, United States.
Druv BhagavanDevelopmental Biomedical Engineering, Washington University, St. Louis, United States.
Jonathan R SilvaDevelopmental Biomedical Engineering, Washington University, St. Louis, United States.ORCID 0000-0002-3696-3955
Jeanne M NerbonneDepartments of Medicine, Cardiovascular Division, Washington University, St. Louis, United States.ORCID 0000-0001-8334-8499
Washington University in St. Louis · US

Funding

PRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6M
FGF14 IN THE REGULATION OF PURKINJE NEURON EXCITABILITY AND SCA27R01NS065761 · NINDS · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M., ORNITZ, DAVID M · 2009 to 2013
$1.9M
MODULATION OF CARDIAC NAV CHANNEL FUNCTION AND ELECTROPHYSIOLOGY BY INTERACTING MOLECULESR01HL136553 · NHLBI · WASHINGTON UNIVERSITY · PI SILVA, JONATHAN R · 2017 to 2021
$1.9M
Training in Integrative and Systems Biology of Cardiovascular DiseaseT32HL134635 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2017 to 2021
$1.8M
Tsc1 Regulation of Purkinje Neuron Firing and Cerebellar FunctionR15NS125560 · NINDS · MIAMI UNIVERSITY OXFORD · PI RANSDELL, JOSEPH L. · 2022 to 2022
$361k
iFGF14 Regulation of Cerebellar Neuron ExcitabilityF32NS090765 · NINDS · WASHINGTON UNIVERSITY · PI RANSDELL, JOSEPH L. · 2014 to 2017
$167k
NHLBI NIH HHS R01 HL136553NHLBI NIH HHS T32 HL007081NHLBI NIH HHS T32 HL134635NINDS NIH HHS F32 NS090765NINDS NIH HHS R01 NS065761NINDS NIH HHS R15 NS125560
6 · The paper itself

Abstract

The resurgent component of the voltage-gated sodium current (I

Indexed as

Ion Channel GatingAction PotentialsAnimalsAnimals, NewbornCerebellumFemaleKineticsMaleMiceMice, Inbred C57BLNeuronsPatch-Clamp TechniquesPostural BalancePurkinje CellsSodiumVoltage-Gated Sodium Channel beta-4 SubunitScn4b protein, mouseSodiumVoltage-Gated Sodium Channel beta-4 Subunitcerebellar Purkinje neuronsINaRmarkov modelingmouseNav channel gatingneurosciencesodium channel gating

Identifiers

PMID35076394
PMCPMC8824471
OpenAlexW4220954832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.