Evidence map›Paper›PMID 35076278›Full record

ArticlemSystems2022

Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice.

Valery V Lozada-Fernández, Orlando deLeon, Stephanie L Kellogg, Fatima L Saravia, Matthew A Hadiono, Samantha N Atkinson, Justin L Grobe, John R Kirby

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Gut microbiome and bile acid changes after male rodent sleeve gastrectomy: what comes first?American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  5. Review
  6. Article
  7. The role of NADnpj metabolic health and disease · 2025
    Review
  8. Article
  9. Review
  10. Nicotinamide Riboside, a Promising Vitamin BMolecules (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Epithelial NADFrontiers in immunology · 2023
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Valery V Lozada-FernándezDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Orlando deLeonDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.
Stephanie L KelloggDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Fatima L SaraviaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew A HadionoDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Samantha N AtkinsonDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Justin L GrobeDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
John R KirbyDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Medical College of Wisconsin · USUniversity of Chicago · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Lysine Acetylation in N. gonorrhoeae Quorum Sensing and Biofilm FormationR01AI108255 · NIAID · UNIVERSITY OF IOWA · PI KIRBY, JOHN R, SCHILLING, BIRGIT · 2014 to 2018
$4.1M
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL134850NIAID NIH HHS R01 AI108255NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

The gut microbiome plays an essential role in host energy homeostasis and influences the development of obesity and related conditions. Studies demonstrate that nicotinamide riboside (NR) supplementation for diet-induced obesity (DIO) reduces weight gain and increases energy expenditure in mice. NR is a vitamin B

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeAnimalsDiet, High-FatHumansMaleMiceMice, Inbred C57BLNADNiacinamideObesityPyridinium CompoundsVitaminsWeight GainNADNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsVitaminsdiet-induced obesityenergy expenditurefecal material transferhigh-fat dietnicotinamide riboside

Identifiers

PMID35076278
PMCPMC8788325
OpenAlexW4206987838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.