Evidence map›Paper›PMID 35076166›Full record

ArticleBrain and behavior2022

Estimating longitudinal depressive symptoms from smartphone data in a transdiagnostic cohort.

Amelia M Pellegrini, Emily J Huang, Patrick C Staples, Kamber L Hart, Jeanette M Lorme, Hannah E Brown, Roy H Perlis, Jukka-Pekka J Onnela

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A Systematic Review of Location Data for Depression Prediction.International journal of environmental research and public health · 2023
    Pooled it
  4. Observational
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Observational
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Amelia M PellegriniCenter for Quantitative Health, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-9312-7673
Emily J HuangDepartment of Mathematics and Statistics, Wake Forest University, Winston-Salem, NC, USA.
Patrick C StaplesDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kamber L HartCenter for Quantitative Health, Massachusetts General Hospital, Boston, MA, USA.
Jeanette M LormeDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hannah E BrownDepartment of Psychiatry, Boston Medical Center, Boston, MA, USA.
Roy H PerlisCenter for Quantitative Health, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5862-6757
Jukka-Pekka J OnnelaDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USBoston Medical Center · USWake Forest University · US

Funding

Research ProjectP50MH106933 · NIMH · HARVARD MEDICAL SCHOOL · PI KOHANE, ISAAC S. · 2014 to 2018
$17.0M
Using mobile phones for social and behavioral sensing of mood disorder patientsDP2MH103909 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI ONNELA, JUKKA-PEKKA · 2013 to 2013
$2.4M
Foundation for the National Institutes of Health 1DP2MH103909NIMH NIH HHS 1P50MH106933NIMH NIH HHS DP2 MH103909NIMH NIH HHS P50 MH106933
6 · The paper itself

Abstract

backgroundPassive measures collected using smartphones have been suggested to represent efficient proxies for depression severity, but the performance of such measures across diagnoses has not been studied.

methodsWe enrolled a cohort of 45 individuals (11 with major depressive disorder, 11 with bipolar disorder, 11 with schizophrenia or schizoaffective disorder, and 12 individuals with no axis I psychiatric disorder). During the 8-week study period, participants were evaluated with a rater-administered Montgomery-Åsberg Depression Rating Scale (MADRS) biweekly, completed self-report PHQ-8 measures weekly on their smartphone, and consented to collection of smartphone-based GPS and accelerometer data in order to learn about their behaviors. We utilized linear mixed models to predict depression severity on the basis of phone-based PHQ-8 and passive measures.

resultsAmong the 45 individuals, 38 (84%) completed the 8-week study. The average root-mean-squared error (RMSE) in predicting the MADRS score (scale 0-60) was 4.72 using passive data alone, 4.27 using self-report measures alone, and 4.30 using both.

conclusionsWhile passive measures did not improve MADRS score prediction in our cross-disorder study, they may capture behavioral phenotypes that cannot be measured objectively, granularly, or over long-term via self-report.

Indexed as

Bipolar DisorderMajor Depressive DisorderDepressionHumansPsychiatric Status Rating ScalesSelf ReportSmartphonebipolar disorderecological momentary assessmentmajor depressive disordermobile applicationsschizophreniaself reportsmartphone

Identifiers

PMID35076166
PMCPMC8865149
OpenAlexW4210719853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.