ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Benefits of a Skull-Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transcranial laser therapy for acute ischaemic stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Photobiomodulation effects on cognitive function - a systematic review and meta-analysis of randomized controlled trials.Lasers in medical science · 2025Pooled it
- Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism.eLife · 2026Article
- Transcranial photobiomodulation mitigates neuroinflammation by suppressing the activation of neurotoxic microglia through inhibition of the cGAS-STING pathway following intracerebral hemorrhage in mice.Chinese medical journal · 2026Article
- Peiminine-Induced Selective Autophagy of AIM2 Inflammasomes Rescues Cerebral Ischemic Injury.Journal of the American Heart Association · 2026Article
- Transcranial photobiomodulation with near-infrared laser induces analgesia in rats.The Journal of physiology · 2026Article
- Application of non-invasive transcranial photobiomodulation in ischemic stroke: Mechanisms and current insights.iScience · 2026Review
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
- Application of photobiomodulation in post-stroke dysfunctions: a literature review of recent clinical studies.Frontiers in neurology · 2026Review
- Challenges and opportunities in next-generation LED therapeutic devices.Light, science & applications · 2025Review
- Hybrid Electro-optical Stimulation Improves Ischemic Brain Damage by Augmenting the Glymphatic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets.Molecular biomedicine · 2025Review
- Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury.Translational psychiatry · 2025Article
- Photobiomodulation: shining a light on depression.Theranostics · 2025Review
- Accelerated Molecular Transportation in the Brain Extracellular Space with 755-nm Light Attenuates Post-Stroke Cognitive Impairment in Rats.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Potential and Challenges of Transcranial Photobiomodulation for the Treatment of Stroke.CNS neuroscience & therapeutics · 2024Review
- Activation of testosterone-androgen receptor mediates cerebrovascular protection by photobiomodulation treatment in photothrombosis-induced stroke rats.CNS neuroscience & therapeutics · 2024Article
- Parkinson's Disease and Photobiomodulation: Potential for Treatment.Journal of personalized medicine · 2024Review
- Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends.Neurophotonics · 2024Review
- Exosomes Derived from M2 Microglial Cells Modulated by 1070-nm Light Improve Cognition in an Alzheimer's Disease Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light-emitting diodes (LEDs) that incorporates a flexible substrate for in vivo brain PBM in a mouse model is developed. Using this device platform, the preventive and therapeutic effects of PBM affixed to the exposed skull of mice in the photothrombosis and middle cerebral artery occlusion stroke model are evaluated. Among the wavelength range of 630, 850, and 940 nm LED array, the PBM with 630-nm LED array is proved to be the most effective for reducing the infarction volume and neurological impairment after ischemic stroke. Moreover, the PBM with 630 nm LED array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates AIM2 inflammasome activation and inflammasome-mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. Thus, PBM may prevent tissue and functional damage in acute ischemic injury, thereby attenuating the development of cognitive impairment after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.