Evidence map›Paper›PMID 35076067›Full record

ArticlePhysical therapy2022

Multisite Transcutaneous Spinal Stimulation for Walking and Autonomic Recovery in Motor-Incomplete Tetraplegia: A Single-Subject Design.

Soshi Samejima, Charlotte D Caskey, Fatma Inanici, Siddhi R Shrivastav, Lorie N Brighton, Jared Pradarelli, Vincente Martinez, Katherine M Steele, Rajiv Saigal, Chet T Moritz

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07325149 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength.

TypeinterventionalSponsorBronx VA Medical CenterRan2026 to 2033Enrolled24ConditionsSecondary Osteoporosis, SarcopeniaArmsExoskeleton-Assisted Walking (EAW) + active Transcutaneous Spinal Cord Stimulation (tSCS), Exoskeleton-assisted walking (EAW) + sham Transcutaneous Spinal Cord Stimulation (tSCS)
NCT07418398 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2026 to 2032Enrolled24ConditionsSpinal Cord InjuryArmsExoskeleton-Assisted Walking (EAW), Sham Transcutaneous Spinal Cord Stimulation (tSCS), Active Transcutaneous Spinal Cord Stimulation (tSCS)
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Soshi SamejimaDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-3796-8085
Charlotte D CaskeyDepartment of Mechanical Engineering, University of Washington, Seattle, Washington, USA.
Fatma InaniciDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
Siddhi R ShrivastavDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
Lorie N BrightonDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
Jared PradarelliDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
Vincente MartinezDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
Katherine M SteeleDepartment of Mechanical Engineering, University of Washington, Seattle, Washington, USA.
Rajiv SaigalDepartment of Neurological Surgery, University of Washington, Seattle, Washington, USA.
Chet T MoritzDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the effect of cervical and lumbar transcutaneous spinal cord stimulation (tSCS) combined with intensive training to improve walking and autonomic function after chronic spinal cord injury (SCI).

methodsTwo 64-year-old men with chronic motor incomplete cervical SCI participated in this single-subject design study. They each underwent 2 months of intensive locomotor training and 2 months of multisite cervical and lumbosacral tSCS paired with intensive locomotor training.

resultsThe improvement in 6-Minute Walk Test distance after 2 months of tSCS with intensive training was threefold greater than after locomotor training alone. Both participants improved balance ability measured by the Berg Balance Scale and increased their ability to engage in daily home exercises. Gait analysis demonstrated increased step length for each individual. Both participants experienced improved sensation and bowel function, and 1 participant eliminated the need for intermittent catheterization after the stimulation phase of the study.

conclusionThese results suggest that noninvasive spinal cord stimulation might promote recovery of locomotor and autonomic functions beyond traditional gait training in people with chronic incomplete cervical SCI. IMPACT: Multisite transcutaneous spinal stimulation may induce neuroplasticity of the spinal networks and confer functional benefits following chronic cervical SCI.

Indexed as

Biomechanical PhenomenaCervical VertebraeCombined Modality TherapyExercise TherapyGait Disorders, NeurologicHumansLumbar VertebraeMaleMiddle AgedNeurogenic BowelRecovery of FunctionSpinal Cord InjuriesSpinal Cord StimulationWalk TestAutonomic FunctionChronic Cervical Spinal Cord InjuryLocomotor TrainingNoninvasive Electrical Spinal Stimulation

Identifiers

PMID35076067
PMCPMC8788019
OpenAlexW4205777648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.